Carotid stenosis and the cognitive function

Laszlo K. Sztriha, Dezso Nemeth, Tamas Sefcsik, Laszlo Vecsei

Research output: Contribution to journalArticle

63 Citations (Scopus)


While stroke is a known cause of a cognitive impairment, the relationship between a carotid artery stenosis and the cognitive function in individuals without a history of stroke is less clear. A number of risk factors for vascular disease are related to a cognitive impairment. Hypertension, diabetes mellitus, cigarette smoking, and dyslipidemia are also associated with an increased risk of carotid artery disease. Some studies have suggested that a stenosis of the internal carotid artery may be an independent risk factor for a cognitive impairment. A high-grade stenosis of the internal carotid artery may be associated with a cognitive impairment even without evidence of infarction on magnetic resonance imaging. On the other hand, it is fairly common that patients display a normal cognition despite severe carotid artery disease, highlighting the important role of an efficient collateral blood supply. The possible pathomechanisms of a cognitive impairment include silent embolization and hypoperfusion. Carotid endarterectomy or stenting may lead to a decline in the cognitive function in consequence of microembolic ischemia or intraprocedural hypoperfusion. Conversely, perfusion restoration could improve a cognitive dysfunction that might have occurred from a state of chronic hypoperfusion. It is unclear whether these complex interactions ultimately result in a net improvement or a deterioration of the cognitive function. The evidence available at present does not seem strong enough to include consideration of a loss of cognition as a factor in determining the balance of the risks and benefits of therapy for a carotid stenosis.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Aug 15 2009


  • Carotid stenosis
  • Cognitive function
  • Embolization
  • Endarterectomy
  • Hypoperfusion
  • Neuropsychology
  • Stent

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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