Carotid intima-media thickness and cerebrovascular reactivity in long-term type 1 diabetes mellitus

Péter Siró, Csilla Molnár, E. Katona, Csaba Antek, J. Kollár, Georgios Settakis, B. Fülesdi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose. Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro- and microvascular damage may occur. The aim of the present work was to assess intima-media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM). Methods. Intima-media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV. Results. IDDM patients showed a significantly larger intima-media thickness (0.1 ± 0.02 mm) than healthy controls (0.06 ± 0.006 mm, p <0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 ± 16.1%) than that of the control subjects (38.7 ± 22.8%, p <0.01). Similarly, HV induced a less-pronounced decrease of cerebral blood flow velocity in diabetic subjects (-30.1 ± 13.2%) than in nondiabetics (-37.6 ± 17.0%, p <0.05). Conclusion. Our results refer to early macro- and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro- and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalJournal of Clinical Ultrasound
Volume37
Issue number8
DOIs
Publication statusPublished - Oct 2009

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Carotid Intima-Media Thickness
Breath Holding
Cerebrovascular Circulation
Type 1 Diabetes Mellitus
Hyperventilation
Blood Flow Velocity
Diabetes Mellitus
Cerebrovascular Disorders
Middle Cerebral Artery
Vasoconstrictor Agents
Prospective Studies

Keywords

  • Cerebral macro
  • Cerebral vasoreactivity
  • IDDM
  • Intima-media thickness
  • Microangiopathy
  • Transcranial Doppler

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Carotid intima-media thickness and cerebrovascular reactivity in long-term type 1 diabetes mellitus. / Siró, Péter; Molnár, Csilla; Katona, E.; Antek, Csaba; Kollár, J.; Settakis, Georgios; Fülesdi, B.

In: Journal of Clinical Ultrasound, Vol. 37, No. 8, 10.2009, p. 451-456.

Research output: Contribution to journalArticle

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abstract = "Purpose. Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro- and microvascular damage may occur. The aim of the present work was to assess intima-media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM). Methods. Intima-media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV. Results. IDDM patients showed a significantly larger intima-media thickness (0.1 ± 0.02 mm) than healthy controls (0.06 ± 0.006 mm, p <0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 ± 16.1{\%}) than that of the control subjects (38.7 ± 22.8{\%}, p <0.01). Similarly, HV induced a less-pronounced decrease of cerebral blood flow velocity in diabetic subjects (-30.1 ± 13.2{\%}) than in nondiabetics (-37.6 ± 17.0{\%}, p <0.05). Conclusion. Our results refer to early macro- and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro- and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM.",
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AU - Settakis, Georgios

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N2 - Purpose. Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro- and microvascular damage may occur. The aim of the present work was to assess intima-media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM). Methods. Intima-media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV. Results. IDDM patients showed a significantly larger intima-media thickness (0.1 ± 0.02 mm) than healthy controls (0.06 ± 0.006 mm, p <0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 ± 16.1%) than that of the control subjects (38.7 ± 22.8%, p <0.01). Similarly, HV induced a less-pronounced decrease of cerebral blood flow velocity in diabetic subjects (-30.1 ± 13.2%) than in nondiabetics (-37.6 ± 17.0%, p <0.05). Conclusion. Our results refer to early macro- and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro- and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM.

AB - Purpose. Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro- and microvascular damage may occur. The aim of the present work was to assess intima-media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM). Methods. Intima-media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV. Results. IDDM patients showed a significantly larger intima-media thickness (0.1 ± 0.02 mm) than healthy controls (0.06 ± 0.006 mm, p <0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 ± 16.1%) than that of the control subjects (38.7 ± 22.8%, p <0.01). Similarly, HV induced a less-pronounced decrease of cerebral blood flow velocity in diabetic subjects (-30.1 ± 13.2%) than in nondiabetics (-37.6 ± 17.0%, p <0.05). Conclusion. Our results refer to early macro- and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro- and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM.

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KW - Transcranial Doppler

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