Carotid artery stiffness is not related to endothelial function in young healthy subjects

Tamas Horvath, Alexandra Pinter, Mark Kollai

Research output: Contribution to journalArticle

7 Citations (Scopus)


Introduction: Carotid artery stiffness, an important determinant of arterial baroreflex sensitivity, varies considerably in healthy individuals, the source of which variability is not known. Tonic relaxant influence of the endothelium on vascular smooth muscle, reducing stiffness of the vessel wall, has been established in muscular conduit arteries. It is not known to what extent stiffness of the elastic carotid artery is under endothelial control. Subjects and methods: Seventy-one healthy male volunteers were studied. Endothelial function was assessed by brachial artery flow mediated dilatation (FMD) normalized by diastolic shear rate (SRd). Carotid artery elastic parameters were determined by echo wall-tracking and tonometry. Systemic arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Results: In univariate analysis carotid artery elastic parameters were related to BMI and systolic blood pressure, but were not related to any of endothelial function parameters. As expected, PWV was related inversely to nFMD. No relation was found between vascular stiffness parameters and endothelium-independent dilation (EID). Conclusion: Carotid artery elasticity in health is not related to conduit artery FMD, suggesting that endothelial influence on baroreceptor activity is not exerted through changes in barosensory wall elasticity.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1-2
Publication statusPublished - Jan 26 2012



  • Arterial stiffness
  • Baroreceptors
  • Carotid artery
  • Endothelial function
  • Flow-mediated dilation
  • NO

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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