Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid

B. Melegh, Maria Pap, Eva Morava, D. Molnár, Maria Dani, Judit Kurucz

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29 Citations (Scopus)

Abstract

Energy metabolism was measured in children receiving long-term treatment with valproic acid. In 8 of 10 randomly selected subjects, the resting respiratory quotient was higher than in age- and sex-matched control subjects (0.91 ± 0.01 vs 0.87 ± 0.01; p -1 · day-1), which was accompanied by increased utilization of carbohydrates (5.31 ± 0.79 vs 3.81 ± 0.39 gm · kg-1 · day-1) in comparison with the control subjects. The resting total energy expenditure was not affected by the treatment. The children with an altered energy consumption pattern (n = 8) received carnitine supplementation for a month; the respiratory quotient then decreased (0.87 ± 0.02), the oxidation of fats increased (1.42 ± 0.25), and the consumption of carbohydrates decreased (3.87 ± 0.79), but no changes in resting energy expenditure were observed. We conclude that carnitine depletion, a known adverse effect of valproic acid administration, may result in inhibited fatty acid oxidation, leading to a shift of substrates utilized from fats to carbohydrates. (J PEDIATR 1994;125:317-21).

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalThe Journal of pediatrics
Volume125
Issue number2
DOIs
Publication statusPublished - 1994

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Carnitine
Valproic Acid
Energy Metabolism
Carbohydrates
Fats
Fatty Acids
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. / Melegh, B.; Pap, Maria; Morava, Eva; Molnár, D.; Dani, Maria; Kurucz, Judit.

In: The Journal of pediatrics, Vol. 125, No. 2, 1994, p. 317-321.

Research output: Contribution to journalArticle

Melegh, B. ; Pap, Maria ; Morava, Eva ; Molnár, D. ; Dani, Maria ; Kurucz, Judit. / Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. In: The Journal of pediatrics. 1994 ; Vol. 125, No. 2. pp. 317-321.
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