Cardiovascular risk assessment in children following kidney transplantation

Arianna Dégi, Andrea Kerti, Éva Kis, Orsolya Cseprekál, Kálmán Tory, Attila J. Szabó, George S. Reusz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

CV diseases are the leading cause of death among patients with ESRD. RTX decreases the CV risk; however, it still remains definitely higher than that of the general population. Large multicenter and longitudinal studies are difficult to perform and hard end-points of CV events are usually missing among pediatric population. Thus, appropriate estimation of CV risk is of crucial importance to define the potential hazards and to evaluate the effect of treatments aimed to reduce the risk. A number of validated non-invasive methods are available to assess the extent of CV damage in adults, such as calcification scores, cIMT, aPWV, 24-h ABPM, AASI, and HRV; however, they need adaptation, standardization, and validation in pediatric studies. cIMT and PWV are the most promising methods, as pediatric normative values are already present. The up-to-date treatment of ESRD aims not only to save life, but to offer the patient a life expectancy approaching that of the healthy population and to ensure a reasonable quality of life.

Original languageEnglish
Pages (from-to)564-576
Number of pages13
JournalPediatric Transplantation
Volume16
Issue number6
DOIs
Publication statusPublished - Sep 1 2012

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Keywords

  • children
  • end-stage renal disease
  • heart
  • renal transplantation
  • risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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