Cardiovascular effects of neuropeptide FF antagonists

Laszlo Prokai, Alevtina D. Zharikova, A. Juhász, Katalin Prokai-Tatrai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 μmol/kg body weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and without a subsequent NPFF challenge.

Original languageEnglish
Pages (from-to)1015-1019
Number of pages5
JournalPeptides
Volume27
Issue number5
DOIs
Publication statusPublished - May 2006

Fingerprint

Blood pressure
Blood Pressure
Hemodynamics
Intravenous Injections
Rats
Arterial Pressure
Heart Rate
Body Weight
phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
Hypertension
Injections
argininamide

Keywords

  • Antagonist
  • Hemodynamic parameters
  • Neuropeptide FF
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Prokai, L., Zharikova, A. D., Juhász, A., & Prokai-Tatrai, K. (2006). Cardiovascular effects of neuropeptide FF antagonists. Peptides, 27(5), 1015-1019. https://doi.org/10.1016/j.peptides.2005.06.032

Cardiovascular effects of neuropeptide FF antagonists. / Prokai, Laszlo; Zharikova, Alevtina D.; Juhász, A.; Prokai-Tatrai, Katalin.

In: Peptides, Vol. 27, No. 5, 05.2006, p. 1015-1019.

Research output: Contribution to journalArticle

Prokai, L, Zharikova, AD, Juhász, A & Prokai-Tatrai, K 2006, 'Cardiovascular effects of neuropeptide FF antagonists', Peptides, vol. 27, no. 5, pp. 1015-1019. https://doi.org/10.1016/j.peptides.2005.06.032
Prokai, Laszlo ; Zharikova, Alevtina D. ; Juhász, A. ; Prokai-Tatrai, Katalin. / Cardiovascular effects of neuropeptide FF antagonists. In: Peptides. 2006 ; Vol. 27, No. 5. pp. 1015-1019.
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