A menopauzális hormonterápia cardiovascularis hatásai

Translated title of the contribution: Cardiovascular effects of menopausal hormone replacement therapy

Research output: Contribution to journalArticle

Abstract

The incidence of coronary heart disease in women rises sharply in the years following menopause. Hormone replacement therapy involves the administration of oestrogen, which provides postmenopausal symptom relief and reverses the changes in calcium and lipid metabolism. Moreover, oestrogen is also postulated to engage multiple mechanisms that defend against hypertension. Early observations suggested that postmenopausal women treated with hormone replacement therapy have significantly reduced cardiovascular risk. However, the results of primary and secondary prevention randomized clinical trials confirmed an increased cardiovascular risk rather than a beneficial effect of hormone replacement therapy in high-risk women. Controversy between results of observational and randomized clinical trials may partly be due to the unexplored genetic background. The authors summarize the effects of oestrogen on lipids, inflammation, haemostatic parameters, blood pressure and vascular wall. Genetic factors that modulate the effect of oestrogen as well as current recommendations on hormone replacement therapy after menopause in high risk women are also presented.

Original languageHungarian
Pages (from-to)225-233
Number of pages9
JournalLege Artis Medicinae
Volume16
Issue number3
Publication statusPublished - Mar 2006

Fingerprint

Hormone Replacement Therapy
Estrogens
Menopause
Randomized Controlled Trials
Hemostatics
Primary Prevention
Secondary Prevention
Lipid Metabolism
Coronary Disease
Blood Vessels
Blood Pressure
Hypertension
Inflammation
Calcium
Lipids
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A menopauzális hormonterápia cardiovascularis hatásai. / Paragh, G.; Harangi, M.

In: Lege Artis Medicinae, Vol. 16, No. 3, 03.2006, p. 225-233.

Research output: Contribution to journalArticle

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