Cardiovascular effects of endocannabinoids - The plot thickens

George Kunos, Zoltán Járai, Károly Varga, Jie Liu, Lei Wang, Jens A. Wagner

Research output: Contribution to journalArticle

38 Citations (Scopus)


Cannabinoids, the bioactive ingredients of the marijuana plant, are best known for their psychoactive properties, but they also influence other physiological processes, such as cardiovascular variables. Endocannabinoids are recently identified lipid mediators that act as natural ligands at cannabinoid receptors and mimic most of the biological effects, including the cardiovascular actions, of plant-derived cannabinoids. In experimental animals, the most prominent component of the cardiovascular effects of cannabinoids is prolonged hypotension and bradycardia. This review focuses on the possible mechanisms underlying these effects. The emerging evidence suggesting that endocannabinoids may be involved in the peripheral regulation of vascular tone under certain conditions is also discussed. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)71-84
Number of pages14
JournalProstaglandins and Other Lipid Mediators
Issue number1-2
Publication statusPublished - Apr 2000



  • 2-Arachidonoyl glycerol
  • Anandamide
  • Blood pressure
  • Vasodilation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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