Cardiovascular autonomic dysfunction in primary Sjögren's syndrome

László Kovács, Dóra Paprika, Róbert Takács, A. Kardos, T. Várkonyi, C. Lengyel, Attila Kovács, L. Rudas, G. Pokorny

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective. To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS). Methods. Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed. Results. The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P <0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P <0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P <0.0001). Conclusion. Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalRheumatology
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2004

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Baroreflex
Autonomic Nervous System
Reflex
Median Neuropathy
Heart Rate
Blood Pressure
Cardiovascular System
Case-Control Studies
Healthy Volunteers
Databases

Keywords

  • Antireceptor antibody
  • Autonomic dysfunction
  • Baroreflex sensitivity
  • Blood pressure variability
  • Cardiovascular reflex test
  • Heart rate variability
  • Primary Sjögren's syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Cardiovascular autonomic dysfunction in primary Sjögren's syndrome. / Kovács, László; Paprika, Dóra; Takács, Róbert; Kardos, A.; Várkonyi, T.; Lengyel, C.; Kovács, Attila; Rudas, L.; Pokorny, G.

In: Rheumatology, Vol. 43, No. 1, 01.2004, p. 95-99.

Research output: Contribution to journalArticle

Kovács, László ; Paprika, Dóra ; Takács, Róbert ; Kardos, A. ; Várkonyi, T. ; Lengyel, C. ; Kovács, Attila ; Rudas, L. ; Pokorny, G. / Cardiovascular autonomic dysfunction in primary Sjögren's syndrome. In: Rheumatology. 2004 ; Vol. 43, No. 1. pp. 95-99.
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AU - Takács, Róbert

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AU - Várkonyi, T.

AU - Lengyel, C.

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