Cardiovascular and thrombophilic risk factors in retinal vein occlusion

Valeria Nagy, Zsuzsa Balogh, Marta Kasza, Bernadett Ujhelyi, Adrienne Csutak, Izabella Reznek, Judit Damjanovich, Andras Berta, Gyorgy Pfliegler

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1 Citation (Scopus)


Retinal Vein Occlusion (RVO) is a retinal disorder resulting in a progressive, severe loss of visual acuity. Its pathogenesis has not yet been clarified. The aim of our study was to investigate cardiovascular and thrombophilic risk factors, and their interaction. 145 RVO patients and 100 control subjects were examined. Protein C, protein S, antithrombin activity, antigen levels, prothrombin G20210A gene polymorphism, factor VIII level, factor V (Leiden) mutation, plasminogen activity, lipoprotein(a), von Willebrand factor, homocysteine and fibrinogen levels and anticardiolipin antibodies were assessed. Possible relevant pathologies (e.g. diabetes mellitus, hypertension and hyperlipidemia) were also registered. Multiple logistic regression analysis revealed that hypertension was a predictive thrombophilic factor in female patients with decreased antithrombin (OR=5.69, 95% CI=2.00-16.14, p=0.0011). Male gender may be a risk factor in patients with normal blood pressure and non-elevated lipoprotein(a) level as well (OR=4.274, 95% CI=1.748-10.448, p=0.0015). Based on our results it appears thatthrombophilia is likely to contribute to the development of RVO, especially if associated with cardiovascular risk factors, like hypertension. In case of justified thrombophilia mainly with hypertension, anticoagulant and/or antiplatelet therapy may be advantageous to prevent fellow eye involvement.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalExperimental and Clinical Cardiology
Issue number1
Publication statusPublished - 2014


  • Cardiovascular risk factors
  • Retinal vein occlusion
  • Thrombophilia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Nagy, V., Balogh, Z., Kasza, M., Ujhelyi, B., Csutak, A., Reznek, I., Damjanovich, J., Berta, A., & Pfliegler, G. (2014). Cardiovascular and thrombophilic risk factors in retinal vein occlusion. Experimental and Clinical Cardiology, 20(1), 238-244.