Cardiovascular and endocrine effects of clonidine premedication in neurosurgical patients

Dorothee M. Gaumann, E. Tassonyi, Robert W. Rivest, Marc Fathi, Alain F. Reverdin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The present study was conducted to examine the haemodynamic and endocrine effects of clonidine, given as sole preanaesthetic medication, in neurosurgical patients. Nineteen patients of ASA physical status I and II, subjected to craniotomy, randomly received po premedication of either clonidine (300 μg, n=9) or placebo (n=10). Blood pressure and heart rate were monitored continuously, while arterial blood samples were collected at specific times, from induction of anaesthesia to recovery, for the measurement of plasma concentrations of epinephrine, norepinephrine, cortisol, aldosterone, and glucose. Clonidine treatment led to a decrease in mean arterial blood pressure (MABP), heart rate (HR), and plasma cortisol and aldosterone concentrations throughout the study, compared with placebo (P

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalCanadian Journal of Anaesthesia
Volume38
Issue number7
DOIs
Publication statusPublished - Oct 1991

Fingerprint

Premedication
Clonidine
Aldosterone
Hydrocortisone
Arterial Pressure
Preanesthetic Medication
Heart Rate
Placebos
Craniotomy
Epinephrine
Norepinephrine
Anesthesia
Hemodynamics
Blood Pressure
Glucose
Therapeutics

Keywords

  • Blood Pressure
  • Heart: rate
  • Hormones: aldosterone, catecholamines, cortisol
  • Metabolism: glucose
  • Surgery: neurosurgery, craniotomy
  • Sympathetic Nervous System: alpha-adrenergic agonist, clonidine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Cardiovascular and endocrine effects of clonidine premedication in neurosurgical patients. / Gaumann, Dorothee M.; Tassonyi, E.; Rivest, Robert W.; Fathi, Marc; Reverdin, Alain F.

In: Canadian Journal of Anaesthesia, Vol. 38, No. 7, 10.1991, p. 837-843.

Research output: Contribution to journalArticle

Gaumann, Dorothee M. ; Tassonyi, E. ; Rivest, Robert W. ; Fathi, Marc ; Reverdin, Alain F. / Cardiovascular and endocrine effects of clonidine premedication in neurosurgical patients. In: Canadian Journal of Anaesthesia. 1991 ; Vol. 38, No. 7. pp. 837-843.
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