Cardiorespiratory effects of recruitment maneuvers and positive end expiratory pressure in an experimental context of acute lung injury and pulmonary hypertension

Camille Doras, Morgan Le Guen, F. Peták, Walid Habre

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Recruitment maneuvers (RM) and positive end expiratory pressure (PEEP) are the cornerstone of the open lung strategy during ventilation, particularly during acute lung injury (ALI). However, these interventions may impact the pulmonary circulation and induce hemodynamic and respiratory effects, which in turn may be critical in case of pulmonary hypertension (PHT). We aimed to establish how ALI and PHT influence the cardiorespiratory effects of RM and PEEP. Methods: Rabbits control or with monocrotaline-induced PHT were used. Forced oscillatory airway and tissue mechanics, effective lung volume (ELV), systemic and right ventricular hemodynamics and blood gas were assessed before and after RM, during baseline and following surfactant depletion by whole lung lavage. Results: RM was more efficient in improving respiratory elastance and ELV in the surfactant-depleted lungs when PHT was concomitantly present. Moreover, the adverse changes in respiratory mechanics and ELV following ALI were lessened in the animals suffering from PHT. Conclusions: During ventilation with open lung strategy, the role of PHT in conferring protection from the adverse respiratory consequences of ALI was evidenced. This finding advocates the safety of RM and PEEP in improving elastance and advancing lung reopening in the simultaneous presence of PHT and ALI.

Original languageEnglish
Article number82
JournalBMC Pulmonary Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - Jul 31 2015

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Positive-Pressure Respiration
Acute Lung Injury
Pulmonary Hypertension
Lung
Surface-Active Agents
Ventilation
Hemodynamics
Monocrotaline
Respiratory Mechanics
Pulmonary Circulation
Bronchoalveolar Lavage
Mechanics
Gases
Rabbits
Safety

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Cardiorespiratory effects of recruitment maneuvers and positive end expiratory pressure in an experimental context of acute lung injury and pulmonary hypertension. / Doras, Camille; Le Guen, Morgan; Peták, F.; Habre, Walid.

In: BMC Pulmonary Medicine, Vol. 15, No. 1, 82, 31.07.2015.

Research output: Contribution to journalArticle

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