Az omega-3 többszörösen telítetlen zsírsavak az atherosclerosis megelozésében

Translated title of the contribution: Cardioprotective role of omega-3 polyunsaturated fatty acids

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cardioprotective action of omega-3 polyunsaturated fatty acids such as cicosapentaenoic and docosahexaenoic acid in fish and α-linolenic acid in plants was demonstrated in primary and secondary clinical trials. Fish oil therapy causes a marked decrease in serum triacylglycerol and very low density lipoprotein levels and increases moderately high density lipoprotein levels without any adverse effects. Omega-3 fatty acids decrease slightly, but significantly blood pressure, enhance endothelial function, they have anti-aggregator, anti-thrombotic and anti-inflammatory effects as well. These beneficial effects are in connection with modification of gene transcription levels of some key molecules such as nuclear factor-κB and sterol element binding receptor protein-1c, which regulate for example expression of adhesion molecules or several receptors involved in triglyceride synthesis (hepatocyte X receptor, hepatocyte nuclear factor 4α, farnesol X receptor, and peroxisome proliferator-activated receptors). On the basis of these observations, the supplementation of the diet with omega-3 fatty acids (fish, fish oil, linseed, and linseed oil or canola oil) is advisable in primary and secondary prevention.

Original languageHungarian
Pages (from-to)627-637
Number of pages11
JournalOrvosi Hetilap
Volume149
Issue number14
DOIs
Publication statusPublished - Apr 6 2008

Fingerprint

Omega-3 Fatty Acids
Unsaturated Fatty Acids
Fish Oils
Fishes
Triglycerides
Hepatocyte Nuclear Factor 4
Farnesol
Linseed Oil
Flax
Peroxisome Proliferator-Activated Receptors
alpha-Linolenic Acid
VLDL Lipoproteins
Docosahexaenoic Acids
Sterols
HDL Lipoproteins
Primary Prevention
Secondary Prevention
Carrier Proteins
Anti-Inflammatory Agents
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az omega-3 többszörösen telítetlen zsírsavak az atherosclerosis megelozésében. / Varga, Z.

In: Orvosi Hetilap, Vol. 149, No. 14, 06.04.2008, p. 627-637.

Research output: Contribution to journalArticle

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