Cardiac vagal hyperactivity in adolescent anorexia nervosa

M. Kollai, I. Bonyhay, G. Jokkel, L. Szonyi

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Adolescent anorexia nervosa, a psychiatric disease with high mortality, is often associated with bradycardia. We studied the vagal control of sinus node function in anorexic subjects, to investigate the mechanism of anorexic bradycardia.Cardiac vagal tone was determined in a group of 11 adolescent anorexic girls and in 11 age- and height-matched controls. Cardiac vagal tone in the anorexic patients was measured as the change in R-R interval in response to complete cholinergic blockade; in addition, non-invasive indices of cardiac vagal tone and baroreflex sensitivity were determined in both anorexic and control subjects. Cardiac vagal tone in anorexic subjects was 465 ± 52 (SE) ms, about 30% higher than values reported for healthy subjects. Vagal tone values were directly related to percent weight loss (R=0. 69, P=0.017). Non-invasive indices of both cardiac vagal activity and baroreflex sensitivity were significantly higher in the anorexic group as compared to controls; the percent increase of cardiac vagal tone, however, exceeded the increase of baroreflex sensitivity.Cardiac vagal hyperactivity significantly contributes to the bradycardia of anorexic subjects. The excess vagal activity is only partly explained by enhanced baroreflex sensitivity.

Original languageEnglish
Pages (from-to)1113-1118
Number of pages6
JournalEuropean Heart Journal
Volume15
Issue number8
Publication statusPublished - Aug 1994

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Baroreflex
Anorexia Nervosa
Cardiac
Bradycardia
Sinoatrial Node
Percent
Cholinergic Agents
Psychiatry
Weight Loss
Healthy Volunteers
Mortality
Excess
Interval
Vertex of a graph

Keywords

  • Baroreflex sensitivity
  • Cholinergic blockade
  • Spectral analysis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kollai, M., Bonyhay, I., Jokkel, G., & Szonyi, L. (1994). Cardiac vagal hyperactivity in adolescent anorexia nervosa. European Heart Journal, 15(8), 1113-1118.

Cardiac vagal hyperactivity in adolescent anorexia nervosa. / Kollai, M.; Bonyhay, I.; Jokkel, G.; Szonyi, L.

In: European Heart Journal, Vol. 15, No. 8, 08.1994, p. 1113-1118.

Research output: Contribution to journalArticle

Kollai, M, Bonyhay, I, Jokkel, G & Szonyi, L 1994, 'Cardiac vagal hyperactivity in adolescent anorexia nervosa', European Heart Journal, vol. 15, no. 8, pp. 1113-1118.
Kollai M, Bonyhay I, Jokkel G, Szonyi L. Cardiac vagal hyperactivity in adolescent anorexia nervosa. European Heart Journal. 1994 Aug;15(8):1113-1118.
Kollai, M. ; Bonyhay, I. ; Jokkel, G. ; Szonyi, L. / Cardiac vagal hyperactivity in adolescent anorexia nervosa. In: European Heart Journal. 1994 ; Vol. 15, No. 8. pp. 1113-1118.
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