Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats

P. Pacher, Z. Ungvari, J. Timar, S. Gyarmati, K. Tekes, V. Keckskemeti

Research output: Contribution to journalArticle

Abstract

Objective: We aimed to investigate the effects of chronic fluoxetine (a selective serotonin reuptake antidepressant inhibitor) treatment (10 mg/kg per os, daily for 6-8 weeks) on action potential (AP) characteristics of isolated right ventricular papillary muscles and left atria of streptozotocin-induced (60 m/kg iv.) diabetic and age-matched control rats. Methods: A conventional glass microelectrode technique was used to record AP parameters. Results: The duration of AP (APD) of diabetic ventricular as well as atrial muscles were significantly increased with no significant differences in the resting membrane potential and maximum rate of the rise of depolarization phase of AP (Vmax or dv/dt). Chronic fluoxetine treatment slightly, but not significantly decreased the action potential amplitude (APA) and Vmax both in control and diabetic groups but did not modify other parameters of APs. Conclusion: The electrophysiological changes found in diabetic heart preparations are mainly due to a decrease in outward K+ current (I(to)), with a possible contribution of altered Ca2+ current(s). Some of these electrophysiological alterations may explain certain characteristic pathological ECG changes (T wave flattening or inversion, reentry arrhytmias) encountered frequently in diabetic patients. Fluoxetine seems to be a well tolerated, safe antidepressant in therapeutic doses even in high risk, diabetic patients, although a slight decrease found in APA and Vmax may indicate that this drug administered in higher doses can exert certain cardiodepressive effects.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalMedical Science Monitor
Volume4
Issue number2
Publication statusPublished - 1998

Fingerprint

Cardiac Electrophysiology
Fluoxetine
Action Potentials
pamidronate
Antidepressive Agents
Therapeutics
Papillary Muscles
Serotonin Uptake Inhibitors
Microelectrodes
Streptozocin
Heart Atria
Membrane Potentials
Glass
Electrocardiography
Muscles
Control Groups
Pharmaceutical Preparations

Keywords

  • Cardiac action potential
  • Diabetes
  • Fluoxetine
  • Rat

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pacher, P., Ungvari, Z., Timar, J., Gyarmati, S., Tekes, K., & Keckskemeti, V. (1998). Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats. Medical Science Monitor, 4(2), 202-208.

Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats. / Pacher, P.; Ungvari, Z.; Timar, J.; Gyarmati, S.; Tekes, K.; Keckskemeti, V.

In: Medical Science Monitor, Vol. 4, No. 2, 1998, p. 202-208.

Research output: Contribution to journalArticle

Pacher, P, Ungvari, Z, Timar, J, Gyarmati, S, Tekes, K & Keckskemeti, V 1998, 'Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats', Medical Science Monitor, vol. 4, no. 2, pp. 202-208.
Pacher P, Ungvari Z, Timar J, Gyarmati S, Tekes K, Keckskemeti V. Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats. Medical Science Monitor. 1998;4(2):202-208.
Pacher, P. ; Ungvari, Z. ; Timar, J. ; Gyarmati, S. ; Tekes, K. ; Keckskemeti, V. / Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats. In: Medical Science Monitor. 1998 ; Vol. 4, No. 2. pp. 202-208.
@article{9898c7f058ac45459ba755a507300d2e,
title = "Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats",
abstract = "Objective: We aimed to investigate the effects of chronic fluoxetine (a selective serotonin reuptake antidepressant inhibitor) treatment (10 mg/kg per os, daily for 6-8 weeks) on action potential (AP) characteristics of isolated right ventricular papillary muscles and left atria of streptozotocin-induced (60 m/kg iv.) diabetic and age-matched control rats. Methods: A conventional glass microelectrode technique was used to record AP parameters. Results: The duration of AP (APD) of diabetic ventricular as well as atrial muscles were significantly increased with no significant differences in the resting membrane potential and maximum rate of the rise of depolarization phase of AP (Vmax or dv/dt). Chronic fluoxetine treatment slightly, but not significantly decreased the action potential amplitude (APA) and Vmax both in control and diabetic groups but did not modify other parameters of APs. Conclusion: The electrophysiological changes found in diabetic heart preparations are mainly due to a decrease in outward K+ current (I(to)), with a possible contribution of altered Ca2+ current(s). Some of these electrophysiological alterations may explain certain characteristic pathological ECG changes (T wave flattening or inversion, reentry arrhytmias) encountered frequently in diabetic patients. Fluoxetine seems to be a well tolerated, safe antidepressant in therapeutic doses even in high risk, diabetic patients, although a slight decrease found in APA and Vmax may indicate that this drug administered in higher doses can exert certain cardiodepressive effects.",
keywords = "Cardiac action potential, Diabetes, Fluoxetine, Rat",
author = "P. Pacher and Z. Ungvari and J. Timar and S. Gyarmati and K. Tekes and V. Keckskemeti",
year = "1998",
language = "English",
volume = "4",
pages = "202--208",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "2",

}

TY - JOUR

T1 - Cardiac electrophysiology of chronic fluoxetine treatment in diabetic rats

AU - Pacher, P.

AU - Ungvari, Z.

AU - Timar, J.

AU - Gyarmati, S.

AU - Tekes, K.

AU - Keckskemeti, V.

PY - 1998

Y1 - 1998

N2 - Objective: We aimed to investigate the effects of chronic fluoxetine (a selective serotonin reuptake antidepressant inhibitor) treatment (10 mg/kg per os, daily for 6-8 weeks) on action potential (AP) characteristics of isolated right ventricular papillary muscles and left atria of streptozotocin-induced (60 m/kg iv.) diabetic and age-matched control rats. Methods: A conventional glass microelectrode technique was used to record AP parameters. Results: The duration of AP (APD) of diabetic ventricular as well as atrial muscles were significantly increased with no significant differences in the resting membrane potential and maximum rate of the rise of depolarization phase of AP (Vmax or dv/dt). Chronic fluoxetine treatment slightly, but not significantly decreased the action potential amplitude (APA) and Vmax both in control and diabetic groups but did not modify other parameters of APs. Conclusion: The electrophysiological changes found in diabetic heart preparations are mainly due to a decrease in outward K+ current (I(to)), with a possible contribution of altered Ca2+ current(s). Some of these electrophysiological alterations may explain certain characteristic pathological ECG changes (T wave flattening or inversion, reentry arrhytmias) encountered frequently in diabetic patients. Fluoxetine seems to be a well tolerated, safe antidepressant in therapeutic doses even in high risk, diabetic patients, although a slight decrease found in APA and Vmax may indicate that this drug administered in higher doses can exert certain cardiodepressive effects.

AB - Objective: We aimed to investigate the effects of chronic fluoxetine (a selective serotonin reuptake antidepressant inhibitor) treatment (10 mg/kg per os, daily for 6-8 weeks) on action potential (AP) characteristics of isolated right ventricular papillary muscles and left atria of streptozotocin-induced (60 m/kg iv.) diabetic and age-matched control rats. Methods: A conventional glass microelectrode technique was used to record AP parameters. Results: The duration of AP (APD) of diabetic ventricular as well as atrial muscles were significantly increased with no significant differences in the resting membrane potential and maximum rate of the rise of depolarization phase of AP (Vmax or dv/dt). Chronic fluoxetine treatment slightly, but not significantly decreased the action potential amplitude (APA) and Vmax both in control and diabetic groups but did not modify other parameters of APs. Conclusion: The electrophysiological changes found in diabetic heart preparations are mainly due to a decrease in outward K+ current (I(to)), with a possible contribution of altered Ca2+ current(s). Some of these electrophysiological alterations may explain certain characteristic pathological ECG changes (T wave flattening or inversion, reentry arrhytmias) encountered frequently in diabetic patients. Fluoxetine seems to be a well tolerated, safe antidepressant in therapeutic doses even in high risk, diabetic patients, although a slight decrease found in APA and Vmax may indicate that this drug administered in higher doses can exert certain cardiodepressive effects.

KW - Cardiac action potential

KW - Diabetes

KW - Fluoxetine

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0031955101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031955101&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031955101

VL - 4

SP - 202

EP - 208

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 2

ER -