Cardiac changes in rheumatoid arthritis.

M. Bély, A. Apáthy, E. Beke-Martos

Research output: Contribution to journalArticle

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Abstract

We reviewed the autopsy material of 169 patients with rheumatoid arthritis (RA) and studied the cardiac changes is these patients. Systemic vasculitis was observed in 26 cases (15.38%) among 169 patients with RA. In 17 cases (10%) we found vasculitis of the subepicardial and/or intramural coronary vessels. Coronary arteritis or arteriolotis has led to multifocal small, and/or large myocardial infarctions in 10 cases (5.9%) and was the cause of progressive cardiac insufficiency, the direct cause of death. Multifocal circumscribed myocardial infarction reported in rheumatoid disease. In 8 cases rheumatoid nodules were found in the myocardium, 3 of them related to vasculitis. We suggest that rheumatoid nodules are the most severe form of necrotizing granulomatous vasculitis. Pathognomic nodular rheumatoid pericarditis was seen in 3 cases and diffuse rheumatoid pericarditis in another case. Pathognomic nodular valvulitis was found in 7 cases. Rheumatoid nodules localized to the epi-, myo-, or endocardium were observed on 9 patients. Generalized secondary amyloidosis was observed in 32 (18.93%) of the 169 patients with RA. Secondary amyloidosis was prevalent in the heart in 29 of 32 cases (relative frequency: 90.62%).

Original languageEnglish
Pages (from-to)149-186
Number of pages38
JournalActa Morphologica Hungarica
Volume40
Issue number1-4
Publication statusPublished - 1992

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Rheumatoid Nodule
Rheumatoid Arthritis
Vasculitis
Pericarditis
Amyloidosis
Myocardium
Myocardial Infarction
Endocardium
Systemic Vasculitis
Arteritis
Cause of Death
Autopsy
Coronary Vessels

ASJC Scopus subject areas

  • Anatomy

Cite this

Bély, M., Apáthy, A., & Beke-Martos, E. (1992). Cardiac changes in rheumatoid arthritis. Acta Morphologica Hungarica, 40(1-4), 149-186.

Cardiac changes in rheumatoid arthritis. / Bély, M.; Apáthy, A.; Beke-Martos, E.

In: Acta Morphologica Hungarica, Vol. 40, No. 1-4, 1992, p. 149-186.

Research output: Contribution to journalArticle

Bély, M, Apáthy, A & Beke-Martos, E 1992, 'Cardiac changes in rheumatoid arthritis.', Acta Morphologica Hungarica, vol. 40, no. 1-4, pp. 149-186.
Bély M, Apáthy A, Beke-Martos E. Cardiac changes in rheumatoid arthritis. Acta Morphologica Hungarica. 1992;40(1-4):149-186.
Bély, M. ; Apáthy, A. ; Beke-Martos, E. / Cardiac changes in rheumatoid arthritis. In: Acta Morphologica Hungarica. 1992 ; Vol. 40, No. 1-4. pp. 149-186.
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