Cardiac arrhythmias: Introduction, electrophysiology of the heart, action potential and membrane currents

N. Jost, Danina M. Muntean, Torsten Christ

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Myocytes represent the functional unit of cardiac muscle; nonetheless, the heart behaves more or less like an electrical syncytium, whose global activity depends on low resistance coupling between the myocytes. The term “more or less” is used here intentionally to imply that while the activity intrinsic to individual myocytes is affected by coupling, its features remain recognizable within the context of the whole heart and are important to determine its function. Electrical changes within the myocytes play an important role to initiate the cardiac contraction. This chapter addresses: (a) the electrical activity of individual myocytes, namely, the resting membrane potentials and action potentials; (b) the way action potentials are conducted throughout the heart to initiate coordinated contraction of the entire heart; and (c) the transmembrane ionic currents underlying cardiac action potential.

Original languageEnglish
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Pages977-1002
Number of pages26
ISBN (Print)9783319159614, 9783319159607
DOIs
Publication statusPublished - Jan 1 2015

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Electrophysiology
Muscle Cells
Action Potentials
Cardiac Arrhythmias
Membranes
Giant Cells
Membrane Potentials
Myocardium

Keywords

  • Action potential
  • Atrial fibrillation
  • AV node
  • Calcium current
  • Cardiac conduction
  • Cardiac membrane potential
  • Electrophysiology
  • Potassium current
  • Transmembrane ion channels

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Jost, N., Muntean, D. M., & Christ, T. (2015). Cardiac arrhythmias: Introduction, electrophysiology of the heart, action potential and membrane currents. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease (pp. 977-1002). Springer International Publishing. https://doi.org/10.1007/978-3-319-15961-4_46

Cardiac arrhythmias : Introduction, electrophysiology of the heart, action potential and membrane currents. / Jost, N.; Muntean, Danina M.; Christ, Torsten.

Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, 2015. p. 977-1002.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jost, N, Muntean, DM & Christ, T 2015, Cardiac arrhythmias: Introduction, electrophysiology of the heart, action potential and membrane currents. in Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, pp. 977-1002. https://doi.org/10.1007/978-3-319-15961-4_46
Jost N, Muntean DM, Christ T. Cardiac arrhythmias: Introduction, electrophysiology of the heart, action potential and membrane currents. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing. 2015. p. 977-1002 https://doi.org/10.1007/978-3-319-15961-4_46
Jost, N. ; Muntean, Danina M. ; Christ, Torsten. / Cardiac arrhythmias : Introduction, electrophysiology of the heart, action potential and membrane currents. Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, 2015. pp. 977-1002
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