Cardiac actions of arachidonic acid

L. Szekeres, J. Borbola, J. Papp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The cardiac actions of arachidonic acid (AA, C 20:4), the precursor of prostaglandin E2 (PGE2) and F(2α)(PGF(2α)) were studied in isolated atria and papillary muscles of guinea pigs as well as canine Purkinje fibers. In contrast to the cardio depressant actions of some short and long chain fatty acids (octanoate, oleate) AA (10-6 - 10-4M) increased sinoatrial rate and contractility in guinea pig atrial preparations. This cardio stimulant action of AA was accompanied by an increase in the amplitude and maximum rate of rise of the intracellularly recorded atrial action potential. Some increase in the resting membrane potential and a slight prolongation of the action potential duration could also be observed. AA did not induce any pace maker activity in isolated papillary muscle of guinea pigs or in isolated Purkinje fibers. Similarly to AA, PGE2 and PGF(2α) (2.1 x 10-8 - 2.1 x 10-5M) were also found to increase atrial rate and contractile force. The stimulating actions of AA were reduced by application of high concentrations of indomethacin (5 x 10-5M). On the basis of these observations it seems reasonable to assume that the cardiac effects of AA are different from those of other fatty acids not possessing PG precursor character, the cardio stimulant actions of AA are presumably related to PGs and/or to an intermediate in the synthesis of PGs.

Original languageEnglish
Pages (from-to)1119-1126
Number of pages8
JournalActa Biologica et Medica Germanica
Volume35
Issue number8-9
Publication statusPublished - 1976

Fingerprint

Dinoprostone
Arachidonic Acid
Purkinje Fibers
Guinea Pigs
Papillary Muscles
Prostaglandins F
Action Potentials
Volatile Fatty Acids
Oleic Acid
Indomethacin
Membrane Potentials
Canidae
Fatty Acids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szekeres, L., Borbola, J., & Papp, J. (1976). Cardiac actions of arachidonic acid. Acta Biologica et Medica Germanica, 35(8-9), 1119-1126.

Cardiac actions of arachidonic acid. / Szekeres, L.; Borbola, J.; Papp, J.

In: Acta Biologica et Medica Germanica, Vol. 35, No. 8-9, 1976, p. 1119-1126.

Research output: Contribution to journalArticle

Szekeres, L, Borbola, J & Papp, J 1976, 'Cardiac actions of arachidonic acid', Acta Biologica et Medica Germanica, vol. 35, no. 8-9, pp. 1119-1126.
Szekeres, L. ; Borbola, J. ; Papp, J. / Cardiac actions of arachidonic acid. In: Acta Biologica et Medica Germanica. 1976 ; Vol. 35, No. 8-9. pp. 1119-1126.
@article{f58652f9dc6d40739c915981d75483c9,
title = "Cardiac actions of arachidonic acid",
abstract = "The cardiac actions of arachidonic acid (AA, C 20:4), the precursor of prostaglandin E2 (PGE2) and F(2α)(PGF(2α)) were studied in isolated atria and papillary muscles of guinea pigs as well as canine Purkinje fibers. In contrast to the cardio depressant actions of some short and long chain fatty acids (octanoate, oleate) AA (10-6 - 10-4M) increased sinoatrial rate and contractility in guinea pig atrial preparations. This cardio stimulant action of AA was accompanied by an increase in the amplitude and maximum rate of rise of the intracellularly recorded atrial action potential. Some increase in the resting membrane potential and a slight prolongation of the action potential duration could also be observed. AA did not induce any pace maker activity in isolated papillary muscle of guinea pigs or in isolated Purkinje fibers. Similarly to AA, PGE2 and PGF(2α) (2.1 x 10-8 - 2.1 x 10-5M) were also found to increase atrial rate and contractile force. The stimulating actions of AA were reduced by application of high concentrations of indomethacin (5 x 10-5M). On the basis of these observations it seems reasonable to assume that the cardiac effects of AA are different from those of other fatty acids not possessing PG precursor character, the cardio stimulant actions of AA are presumably related to PGs and/or to an intermediate in the synthesis of PGs.",
author = "L. Szekeres and J. Borbola and J. Papp",
year = "1976",
language = "English",
volume = "35",
pages = "1119--1126",
journal = "Acta Biologica et Medica Germanica",
issn = "0001-5318",
publisher = "Akademie Verlag GMBH",
number = "8-9",

}

TY - JOUR

T1 - Cardiac actions of arachidonic acid

AU - Szekeres, L.

AU - Borbola, J.

AU - Papp, J.

PY - 1976

Y1 - 1976

N2 - The cardiac actions of arachidonic acid (AA, C 20:4), the precursor of prostaglandin E2 (PGE2) and F(2α)(PGF(2α)) were studied in isolated atria and papillary muscles of guinea pigs as well as canine Purkinje fibers. In contrast to the cardio depressant actions of some short and long chain fatty acids (octanoate, oleate) AA (10-6 - 10-4M) increased sinoatrial rate and contractility in guinea pig atrial preparations. This cardio stimulant action of AA was accompanied by an increase in the amplitude and maximum rate of rise of the intracellularly recorded atrial action potential. Some increase in the resting membrane potential and a slight prolongation of the action potential duration could also be observed. AA did not induce any pace maker activity in isolated papillary muscle of guinea pigs or in isolated Purkinje fibers. Similarly to AA, PGE2 and PGF(2α) (2.1 x 10-8 - 2.1 x 10-5M) were also found to increase atrial rate and contractile force. The stimulating actions of AA were reduced by application of high concentrations of indomethacin (5 x 10-5M). On the basis of these observations it seems reasonable to assume that the cardiac effects of AA are different from those of other fatty acids not possessing PG precursor character, the cardio stimulant actions of AA are presumably related to PGs and/or to an intermediate in the synthesis of PGs.

AB - The cardiac actions of arachidonic acid (AA, C 20:4), the precursor of prostaglandin E2 (PGE2) and F(2α)(PGF(2α)) were studied in isolated atria and papillary muscles of guinea pigs as well as canine Purkinje fibers. In contrast to the cardio depressant actions of some short and long chain fatty acids (octanoate, oleate) AA (10-6 - 10-4M) increased sinoatrial rate and contractility in guinea pig atrial preparations. This cardio stimulant action of AA was accompanied by an increase in the amplitude and maximum rate of rise of the intracellularly recorded atrial action potential. Some increase in the resting membrane potential and a slight prolongation of the action potential duration could also be observed. AA did not induce any pace maker activity in isolated papillary muscle of guinea pigs or in isolated Purkinje fibers. Similarly to AA, PGE2 and PGF(2α) (2.1 x 10-8 - 2.1 x 10-5M) were also found to increase atrial rate and contractile force. The stimulating actions of AA were reduced by application of high concentrations of indomethacin (5 x 10-5M). On the basis of these observations it seems reasonable to assume that the cardiac effects of AA are different from those of other fatty acids not possessing PG precursor character, the cardio stimulant actions of AA are presumably related to PGs and/or to an intermediate in the synthesis of PGs.

UR - http://www.scopus.com/inward/record.url?scp=0017141278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017141278&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 1119

EP - 1126

JO - Acta Biologica et Medica Germanica

JF - Acta Biologica et Medica Germanica

SN - 0001-5318

IS - 8-9

ER -