Meningitis carcinomatosa

Translated title of the contribution: Carcinomatous meningitis

G. Cserni, Vágó Tibor, Török Norbert, Gaál Zoltán, Velkei Tamás, Serényi Péter, Göcz Katalin, Tusa Magdolna, Kovács Katalin, Szucs Miklós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION - Carcinomatous meningitis is a serious complication of advanced stage solid tumours, which may become more common with improved survival. CASE REPORTS - A 53-year-old woman with a recent history of breast cancer (pT2pN2M0) had been treated by mastectomy and adjuvant chemotherapy and radiotherapy. She presented with weakness, diplopia and vertigo raising the possibility of vertebrobasilar ischaemia or an intracranial mass. In another patient, a 62-year-old man with hypertension, a stenotic common bile duct had been diagnosed when examined for abdominal complaints. When he presented with a high blood pressure value accompanied by intensive headache, vomiting and bilateral hearing loss, he was thought to have a hypertensive crisis. The rapidly progressive neurological symptoms and the history of breast cancer and findings suggesting pancreatic head tumour, respectively, led to the clinical diagnosis of carcinomatous meningitis in both cases, despite any evidence on CT scans or a negative MR scan, though of limited value, in the first case. This diagnosis was confirmed by the laboratory and cytological findings of the cerebrospinal fluid, and also by the post mortem examination, since both patients died within a month after the onset of the symptoms. The primary tumour in the second patient proved to be a widely metastasizing diffuse type gastric cancer. CONCLUSION - Carcinomatous meningitis has a varying but characteristic presentation which generally makes it easy to diagnose, but it can sometimes present differential diagnostic problems. What we can learn from these two cases may help in recognizing this complication.

Original languageHungarian
Pages (from-to)688-693
Number of pages6
JournalLege Artis Medicinae
Volume17
Issue number10
Publication statusPublished - Oct 2007

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Meningeal Carcinomatosis
Bilateral Hearing Loss
Breast Neoplasms
Vertebrobasilar Insufficiency
Hypertension
Neoplasms
Adjuvant Radiotherapy
Diplopia
Vertigo
Mastectomy
Common Bile Duct
Adjuvant Chemotherapy
Stomach Neoplasms
Vomiting
Headache
Cerebrospinal Fluid
Autopsy
History
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cserni, G., Tibor, V., Norbert, T., Zoltán, G., Tamás, V., Péter, S., ... Miklós, S. (2007). Meningitis carcinomatosa. Lege Artis Medicinae, 17(10), 688-693.

Meningitis carcinomatosa. / Cserni, G.; Tibor, Vágó; Norbert, Török; Zoltán, Gaál; Tamás, Velkei; Péter, Serényi; Katalin, Göcz; Magdolna, Tusa; Katalin, Kovács; Miklós, Szucs.

In: Lege Artis Medicinae, Vol. 17, No. 10, 10.2007, p. 688-693.

Research output: Contribution to journalArticle

Cserni, G, Tibor, V, Norbert, T, Zoltán, G, Tamás, V, Péter, S, Katalin, G, Magdolna, T, Katalin, K & Miklós, S 2007, 'Meningitis carcinomatosa', Lege Artis Medicinae, vol. 17, no. 10, pp. 688-693.
Cserni G, Tibor V, Norbert T, Zoltán G, Tamás V, Péter S et al. Meningitis carcinomatosa. Lege Artis Medicinae. 2007 Oct;17(10):688-693.
Cserni, G. ; Tibor, Vágó ; Norbert, Török ; Zoltán, Gaál ; Tamás, Velkei ; Péter, Serényi ; Katalin, Göcz ; Magdolna, Tusa ; Katalin, Kovács ; Miklós, Szucs. / Meningitis carcinomatosa. In: Lege Artis Medicinae. 2007 ; Vol. 17, No. 10. pp. 688-693.
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