Carcinogenic potential of trans-2-hexenal is based on epigenetic effect

Edit Nádasi, Tímea Varjas, Lászloó Pajor, I. Ember

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Trans-2-hexenal (2-hexenal) is an α,β-unsaturated carbonyl compound protecting plants against harmful substances. Since humans have a permanent intake of 2-hexenal via vegetable products, this genotoxic and mutagenic compound is considered to play a role in human carcinogenicity. Materials and Methods: Ha-ras and p53 gene expression changes and tumor development were investigated in mice and rats after 2-hexenal administration. Results: 2-Hexenal exposure did not result in gene expression alterations 24, 48 or 72 hours after administration while 10 out of the 72 mice and rats included in the long-term study developed a malignancy by the end of the 18-month follow-up. Conclusion: Our results suggest that, although 2-hexenal showed no effect on the expression of the investigated onco- and suppressor genes, it has a marked carcinogenic potential, which may be explained only by an epigenetic effect of the compound.

Original languageEnglish
Pages (from-to)559-562
Number of pages4
JournalIn Vivo
Volume19
Issue number3
Publication statusPublished - May 2005

Fingerprint

Epigenomics
Gene expression
Rats
Gene Expression
Carbonyl compounds
ras Genes
p53 Genes
Vegetables
Tumor Suppressor Genes
2-hexenal
Tumors
Neoplasms
Genes

Keywords

  • "Short-term" and "long-term" studies
  • Carcinogenic effect
  • Epigenetic effect
  • Gene expression
  • Trans-2-hexenal

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nádasi, E., Varjas, T., Pajor, L., & Ember, I. (2005). Carcinogenic potential of trans-2-hexenal is based on epigenetic effect. In Vivo, 19(3), 559-562.

Carcinogenic potential of trans-2-hexenal is based on epigenetic effect. / Nádasi, Edit; Varjas, Tímea; Pajor, Lászloó; Ember, I.

In: In Vivo, Vol. 19, No. 3, 05.2005, p. 559-562.

Research output: Contribution to journalArticle

Nádasi, E, Varjas, T, Pajor, L & Ember, I 2005, 'Carcinogenic potential of trans-2-hexenal is based on epigenetic effect', In Vivo, vol. 19, no. 3, pp. 559-562.
Nádasi, Edit ; Varjas, Tímea ; Pajor, Lászloó ; Ember, I. / Carcinogenic potential of trans-2-hexenal is based on epigenetic effect. In: In Vivo. 2005 ; Vol. 19, No. 3. pp. 559-562.
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