Carcinogenic effect of N-dinitrosopiperazine and N-nitrosodiaethylamine on aquarium-fishes

K. Simon, K. Lapis, V. Khudoley, G. B. Pliss

Research output: Contribution to journalArticle

Abstract

The authors first show the carcinogenic effect of DNP on fishes. Doses of 50 mg/l and 100 mg/l of DNP dissolved in the water of the aquarium were used. The first tumour (papillomatosis of the esophagus) occurred in the first month of administration of DNP in the mentioned doses. Later polypus of the bowel and hepatocellular carcinoma have developed. The average latency period of the development of tumours was 14 weeks. The carcinogenic effect of DNP was compared to that of the NDEA used as a positive control substance. It was established that NDEA induces alterations similar to that of the DNP. Results of these experiments indicate that the polytrop effect of the DNP is stronger than that of the NDEA, although the latter proved to be a more active carcinogen. In the given experimental circumstances no development of tumours in control animals was seen. Aquarium-fishes, being extremely sensitive to the carcinogenic effect of nitrosamines. may serve as an optimal indicator of pollution of hydrosphaere with carcinogenic substances.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalMorphologiai es igazsagugyi orvosi szemle
Volume22
Issue number4
Publication statusPublished - 1982

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Fishes
Nitrosamines
Neoplasms
Papilloma
Carcinogens
Esophagus
Hepatocellular Carcinoma
Water

ASJC Scopus subject areas

  • Medicine(all)

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Carcinogenic effect of N-dinitrosopiperazine and N-nitrosodiaethylamine on aquarium-fishes. / Simon, K.; Lapis, K.; Khudoley, V.; Pliss, G. B.

In: Morphologiai es igazsagugyi orvosi szemle, Vol. 22, No. 4, 1982, p. 298-303.

Research output: Contribution to journalArticle

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