Carboxylato-pillar[6]arene-based fluorescent indicator displacement assays for the recognition of monoamine neurotransmitters

Adrien Paudics, M. Kubinyi, I. Bitter, Márton Bojtár

Research output: Contribution to journalArticle

Abstract

The complexation of three cationic fluorescent dye guests with the anionic host carboxylato-pillar[6]arene (WP6) was investigated by optical and NMR spectroscopy. Among the selected indicators-a stilbazolium dye (i1) and two naphthalimide derivatives with positively charged 'anchor' groups (i2 and i3)-i1 gave a large turn-on, i2 and i3 a large turn-off fluorescence response to the complexation. The size selectivity of the complex formation of pillararenes was demonstrated by comparing the binding constants of the complexes of the three indicators with WP6 and its smaller homologue, WP5. The systems WP6·i1 and WP6·i2 were tested as indicator displacement assays for the sensing of monoamine neurotransmitters. The WP6·i1 system functioned as a turn-off, the WP6·i2 system as a turn-on sensor for neurotransmitters, and both assays showed a good selectivity to histamine over the other neurotransmitter analytes.

Original languageEnglish
Pages (from-to)16856-16862
Number of pages7
JournalRSC Advances
Volume9
Issue number29
DOIs
Publication statusPublished - Jan 1 2019

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Complexation
Neurotransmitter Agents
Assays
Dyes
Naphthalimides
Anchors
Nuclear magnetic resonance spectroscopy
Fluorescence
Derivatives
Fluorescent Dyes
Histamine
Sensors
Coloring Agents
pillar(6)arene
Optical spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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Carboxylato-pillar[6]arene-based fluorescent indicator displacement assays for the recognition of monoamine neurotransmitters. / Paudics, Adrien; Kubinyi, M.; Bitter, I.; Bojtár, Márton.

In: RSC Advances, Vol. 9, No. 29, 01.01.2019, p. 16856-16862.

Research output: Contribution to journalArticle

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