Carboxylated magnetic nanoparticles as MRI contrast agents: Relaxation measurements at different field strengths

Angéla Jedlovszky-Hajdú, Etelka Tombácz, István Bányai, Magor Babos, András Palkó

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

At the moment the biomedical applications of magnetic fluids are the subject of intensive scientific interest. In the present work, magnetite nanoparticles (MNPs) were synthesized and stabilized in aqueous medium with different carboxylic compounds (citric acid (CA), polyacrylic acid (PAA), and sodium oleate (NaOA)), in order to prepare well stabilized magnetic fluids (MFs). The magnetic nanoparticles can be used in the magnetic resonance imaging (MRI) as contrast agents. Magnetic resonance relaxation measurements of the above MFs were performed at different field strengths (i.e., 0.47, 1.5 and 9.4 T) to reveal the field strength dependence of their magnetic responses, and to compare them with that of ferucarbotran, a well-known superparamagnetic contrast agent. The measurements showed characteristic differences between the tested magnetic fluids stabilized by carboxylic compounds and ferucarbotran. It is worthy of note that our magnetic fluids have the highest r2 relaxivities at the field strength of 1.5 T, where the most of the MRI works in worldwide.

Original languageEnglish
Pages (from-to)3173-3180
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume324
Issue number19
DOIs
Publication statusPublished - Sep 1 2012

    Fingerprint

Keywords

  • Iron oxide nanoparticle
  • MR Imaging
  • Magnetic fluid
  • Nuclear MR

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this