Carbon source regulation of β-galactosidase biosynthesis in Penicillium chrysogenum

Zoltn Nagy, Zsolt Keresztessy, A. Szentirmai, Sndor Bir

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Growth and β-galactosidase activity of the penicillin producer industrial Penicillium chrysogenum NCAIM 00237 strain were examined using different carbon sources. Good growth was observed using glucose, sucrose, glycerol and galactose, while growth on lactose was substantially slower. β-Galactosidase activity was high on lactose and very low on all the other carbon sources tested. In glucose grown cultures after exhaustion of glucose as repressing carbon source a derepressed low level of the enzyme was observed. cAMP concentration in lactose grown cultures was relatively high, in glucose grown cultures was low. Caffeine substantially decreased glucose consumption and growth but did not increase β-galactosidase activity and did not prevent glucose repression which rules out the involvement of cAMP in the regulation of β-galactosidase biosynthesis in Penicillium chrysogenum.

Original languageEnglish
Pages (from-to)351-362
Number of pages12
JournalJournal of Basic Microbiology
Volume41
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Galactosidases
Penicillium chrysogenum
Carbon
Glucose
Lactose
Growth
Caffeine
Galactose
Penicillins
Glycerol
Sucrose
Enzymes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Genetics

Cite this

Carbon source regulation of β-galactosidase biosynthesis in Penicillium chrysogenum. / Nagy, Zoltn; Keresztessy, Zsolt; Szentirmai, A.; Bir, Sndor.

In: Journal of Basic Microbiology, Vol. 41, No. 6, 2001, p. 351-362.

Research output: Contribution to journalArticle

Nagy, Zoltn ; Keresztessy, Zsolt ; Szentirmai, A. ; Bir, Sndor. / Carbon source regulation of β-galactosidase biosynthesis in Penicillium chrysogenum. In: Journal of Basic Microbiology. 2001 ; Vol. 41, No. 6. pp. 351-362.
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