Carbon monoxide: Endogenous mediator, potential diagnostic and therapeutic target

Subhamay Ghosh, J. Gál, Nandor Marczin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The primary objectives of this article are to review the potential role of carbon monoxide (CO) as an endogenous mediator, diagnostic marker for pulmonary disorders, and therapeutic target in critical illness. The review will start by focusing on the importance of the heme oxygenase (HO)-CO axis as an endogenous system as it relates to the cardiovascular and pulmonary systems. It will elucidate the influence of HO gene expression on critical events like shock, sepsis, ischemia-reperfusion and others. Our focus will then shift and look at the potential diagnostic role of exhaled CO in major inflammatory states of the lung, and finally we will highlight the activities on inhaled CO being considered as a possible therapeutic tool and the controversies surrounding it.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalAnnals of Medicine
Volume42
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Carbon Monoxide
Heme Oxygenase (Decyclizing)
Lung
Therapeutics
Cardiovascular System
Critical Illness
Reperfusion
Shock
Sepsis
Ischemia
Gene Expression

Keywords

  • Acute lung injury
  • ARDS
  • Carbon monoxide
  • Cytokines
  • Nitric oxide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Carbon monoxide : Endogenous mediator, potential diagnostic and therapeutic target. / Ghosh, Subhamay; Gál, J.; Marczin, Nandor.

In: Annals of Medicine, Vol. 42, No. 1, 2010, p. 1-12.

Research output: Contribution to journalArticle

Ghosh, Subhamay ; Gál, J. ; Marczin, Nandor. / Carbon monoxide : Endogenous mediator, potential diagnostic and therapeutic target. In: Annals of Medicine. 2010 ; Vol. 42, No. 1. pp. 1-12.
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