Carbohydrate components recognized by the cone‐specific monoclonal antibody CSA‐1 and by peanut agglutinin are associated with red and green‐sensitive cone photoreceptors

Pál Röhlich, Ágoston Szél, Lincoln V. Johnson, Gregory S. Hageman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Previous investigations have demonstrated that the monoclonal antibody CSA‐1 and peanut agglutinin label specifically cone photoreceptor cells. In the present study, we compared the binding of CSA‐1 and peanut agglutinin to that of the monoclonal antibodies COS‐1 and OS‐2, which have been shown to recognize the red/green‐ and blue‐sensitive cone visual pigments, respectively. Using lectin and immunocytochemistry on serial semithin sections of the pig retina, we have demonstrated in the present study that both CSA‐1 and peanut agglutinin label specifically the red‐, and green‐sensitive, but not the blue‐sensitive cone cell outer segments. Peanut agglutinin does bind, however, to the cone matrix sheaths associated with all three types of cones. These observations support the idea that red‐, and green‐sensitive cone cells share some common molecular epitopes and may represent a differentiation line of cones, considerably different from that of blue‐sensitive cones.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalJournal of Comparative Neurology
Volume289
Issue number3
DOIs
Publication statusPublished - Nov 15 1989

Keywords

  • color sensitivity
  • cone‐specific antibodies
  • immunocytochemistry
  • lectin
  • red/green photoreceptors
  • retina

ASJC Scopus subject areas

  • Neuroscience(all)

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