Carbohydrate-based templates for synthetic vaccines and drug delivery

Ross P. McGeary, Istvan Jablonkai, Istvan Toth

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Methyl tetra-O-allyl, and tetra-O-[2-(tetrahydro-2H-pyranyl)oxy.-3-oxapentyl glucosides, and tetra-O-(cyanoethyl)galactosyl azide were converted into derivatives containing linkers with terminal carboxylic acid functionalities at the anomeric position and bearing four arms with phthaloyl- or BOC-protected terminal amino groups. These molecules were suitable for use in solid-phase peptide synthesis and for the preparation of dendrimers containing multiple copies of peptides.

Original languageEnglish
Pages (from-to)8733-8742
Number of pages10
JournalTetrahedron
Volume57
Issue number41
DOIs
Publication statusPublished - Oct 8 2001

Keywords

  • Adjuvants/carriers
  • Carbohydrates
  • Solid-phase synthesis
  • Synthetic vaccines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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