Carbapenem-non-susceptible Enterobacteriaceae in Europe

Conclusions from a meeting of national experts

H. Grundmann, D. M. Livermore, C. G. Giske, R. Canton, G. M. Rossolini, J. Campos, A. Vatopoulos, M. Gniadkowski, A. Tóth, Y. Pfeifer, Vincent Jarlier, Y. Carmeli, Helmut Mittermayer, Mathijs Goossens, Nijaz Tihic, Yuliha Proevska, Arjana Tambic, Despo Pieridou-Bagatzouni, Helena Zemlickova, Jaroslav Hrabak & 35 others Anette M. Hammerum, Marina Ivanova, Jari Jalavi, Yvonne Pfeifer, Alkis Vatopoulos, Akos Toth, Hordur Hardarson, Teck Wee Boo, Raul Colodner, Yehuda Carmeli, Monica Monaco, Aurora Garcia-Fernandez, Gianni Rossolini, Arta Balode, Jolanta Miciuleviciene, Paul Caruana, Gunnar Skov, Orjan Samuelsen, Waleria Hryniewicz, Marek Gniadkowski, Manuela Caniça, Vera Manageiro, Irina Codita, Manica Mueller-Premru, Jana Kolman, Jose Campos, Jesus Oteo Iglesias, Rafael Cantón, Petra J. Edquist, Christian Giske, Sara Droz, David Livermore, Maurine A. Leverstein - van Hall, Xander Huijsdens, Hajo Grundmann

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

The emergence and global spread of carbapenemaseproducing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiology is compounded by the diversity of carbapenem-hydrolysing enzymes and the ability of their genes to spread between different bacterial species. Difficulties are also encountered by laboratories when trying to detect carbapenemase production during routine diagnostic procedures due to an often heterogeneous expression of resistance. Some of the resistance genes are associated with successful clonal lineages which have a selective advantage in those hospitals where antimicrobial use is high and opportunities for transmission exist; others are more often associated with transmissible plasmids. A genetically distinct strain of Klebsiella pneumoniae sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) has been causing epidemics of national and international proportions. It follows the pathways of patient referrals, causing hospital outbreaks along the way. Simultaneously, diverse strains harbouring New Delhi metallo-beta-lactamase (NDM-1) are repeatedly being imported into Europe, commonly via patients with prior medical exposure in the Indian subcontinent. Since the nature and scale of carbapenem-non-susceptible Entrobacteriaceae as a threat to hospital patients in Europe remains unclear, a consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner.

Original languageEnglish
JournalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
Volume15
Issue number46
Publication statusPublished - Nov 18 2010

Fingerprint

Carbapenems
Enterobacteriaceae
Klebsiella pneumoniae
Referral and Consultation
Anti-Bacterial Agents
beta-Lactams
Genes
Health Services
Disease Outbreaks
Epidemiology
Plasmids
Public Health
Bacteria
Enzymes
beta-lactamase NDM-1
Therapeutics

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Carbapenem-non-susceptible Enterobacteriaceae in Europe : Conclusions from a meeting of national experts. / Grundmann, H.; Livermore, D. M.; Giske, C. G.; Canton, R.; Rossolini, G. M.; Campos, J.; Vatopoulos, A.; Gniadkowski, M.; Tóth, A.; Pfeifer, Y.; Jarlier, Vincent; Carmeli, Y.; Mittermayer, Helmut; Goossens, Mathijs; Tihic, Nijaz; Proevska, Yuliha; Tambic, Arjana; Pieridou-Bagatzouni, Despo; Zemlickova, Helena; Hrabak, Jaroslav; Hammerum, Anette M.; Ivanova, Marina; Jalavi, Jari; Pfeifer, Yvonne; Vatopoulos, Alkis; Toth, Akos; Hardarson, Hordur; Wee Boo, Teck; Colodner, Raul; Carmeli, Yehuda; Monaco, Monica; Garcia-Fernandez, Aurora; Rossolini, Gianni; Balode, Arta; Miciuleviciene, Jolanta; Caruana, Paul; Skov, Gunnar; Samuelsen, Orjan; Hryniewicz, Waleria; Gniadkowski, Marek; Caniça, Manuela; Manageiro, Vera; Codita, Irina; Mueller-Premru, Manica; Kolman, Jana; Campos, Jose; Oteo Iglesias, Jesus; Cantón, Rafael; Edquist, Petra J.; Giske, Christian; Droz, Sara; Livermore, David; Leverstein - van Hall, Maurine A.; Huijsdens, Xander; Grundmann, Hajo.

In: Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin, Vol. 15, No. 46, 18.11.2010.

Research output: Contribution to journalArticle

Grundmann, H, Livermore, DM, Giske, CG, Canton, R, Rossolini, GM, Campos, J, Vatopoulos, A, Gniadkowski, M, Tóth, A, Pfeifer, Y, Jarlier, V, Carmeli, Y, Mittermayer, H, Goossens, M, Tihic, N, Proevska, Y, Tambic, A, Pieridou-Bagatzouni, D, Zemlickova, H, Hrabak, J, Hammerum, AM, Ivanova, M, Jalavi, J, Pfeifer, Y, Vatopoulos, A, Toth, A, Hardarson, H, Wee Boo, T, Colodner, R, Carmeli, Y, Monaco, M, Garcia-Fernandez, A, Rossolini, G, Balode, A, Miciuleviciene, J, Caruana, P, Skov, G, Samuelsen, O, Hryniewicz, W, Gniadkowski, M, Caniça, M, Manageiro, V, Codita, I, Mueller-Premru, M, Kolman, J, Campos, J, Oteo Iglesias, J, Cantón, R, Edquist, PJ, Giske, C, Droz, S, Livermore, D, Leverstein - van Hall, MA, Huijsdens, X & Grundmann, H 2010, 'Carbapenem-non-susceptible Enterobacteriaceae in Europe: Conclusions from a meeting of national experts', Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin, vol. 15, no. 46.
Grundmann, H. ; Livermore, D. M. ; Giske, C. G. ; Canton, R. ; Rossolini, G. M. ; Campos, J. ; Vatopoulos, A. ; Gniadkowski, M. ; Tóth, A. ; Pfeifer, Y. ; Jarlier, Vincent ; Carmeli, Y. ; Mittermayer, Helmut ; Goossens, Mathijs ; Tihic, Nijaz ; Proevska, Yuliha ; Tambic, Arjana ; Pieridou-Bagatzouni, Despo ; Zemlickova, Helena ; Hrabak, Jaroslav ; Hammerum, Anette M. ; Ivanova, Marina ; Jalavi, Jari ; Pfeifer, Yvonne ; Vatopoulos, Alkis ; Toth, Akos ; Hardarson, Hordur ; Wee Boo, Teck ; Colodner, Raul ; Carmeli, Yehuda ; Monaco, Monica ; Garcia-Fernandez, Aurora ; Rossolini, Gianni ; Balode, Arta ; Miciuleviciene, Jolanta ; Caruana, Paul ; Skov, Gunnar ; Samuelsen, Orjan ; Hryniewicz, Waleria ; Gniadkowski, Marek ; Caniça, Manuela ; Manageiro, Vera ; Codita, Irina ; Mueller-Premru, Manica ; Kolman, Jana ; Campos, Jose ; Oteo Iglesias, Jesus ; Cantón, Rafael ; Edquist, Petra J. ; Giske, Christian ; Droz, Sara ; Livermore, David ; Leverstein - van Hall, Maurine A. ; Huijsdens, Xander ; Grundmann, Hajo. / Carbapenem-non-susceptible Enterobacteriaceae in Europe : Conclusions from a meeting of national experts. In: Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin. 2010 ; Vol. 15, No. 46.
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abstract = "The emergence and global spread of carbapenemaseproducing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiology is compounded by the diversity of carbapenem-hydrolysing enzymes and the ability of their genes to spread between different bacterial species. Difficulties are also encountered by laboratories when trying to detect carbapenemase production during routine diagnostic procedures due to an often heterogeneous expression of resistance. Some of the resistance genes are associated with successful clonal lineages which have a selective advantage in those hospitals where antimicrobial use is high and opportunities for transmission exist; others are more often associated with transmissible plasmids. A genetically distinct strain of Klebsiella pneumoniae sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) has been causing epidemics of national and international proportions. It follows the pathways of patient referrals, causing hospital outbreaks along the way. Simultaneously, diverse strains harbouring New Delhi metallo-beta-lactamase (NDM-1) are repeatedly being imported into Europe, commonly via patients with prior medical exposure in the Indian subcontinent. Since the nature and scale of carbapenem-non-susceptible Entrobacteriaceae as a threat to hospital patients in Europe remains unclear, a consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner.",
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AU - Grundmann, H.

AU - Livermore, D. M.

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AU - Canton, R.

AU - Rossolini, G. M.

AU - Campos, J.

AU - Vatopoulos, A.

AU - Gniadkowski, M.

AU - Tóth, A.

AU - Pfeifer, Y.

AU - Jarlier, Vincent

AU - Carmeli, Y.

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