Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland

Péter Enyedi, Bertil B. Fredholm, Jan M. Lundberg, Anders Änggård

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effect of VIP and carbachol on cyclic AMP production were studied in isolated acini of the cat submandibular gland and guinea pig pancreas. VIP was almost 100 times more potent in stimulating cyclic AMP in the pancreas than in the submandibular salivary gland. Carbachol did not influence cyclic AMP in the pancreas while a 20-30% increase was seen in the submandibular gland. The addition of carbachol potentiated the cyclic AMP response to VIP in the submandibular acini while no such effect was observed in the pancreas. Atropine abolished the effect of carbachol.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalEuropean Journal of Pharmacology
Volume79
Issue number1-2
DOIs
Publication statusPublished - Apr 8 1982

Fingerprint

Submandibular Gland
Carbachol
Cyclic AMP
Pancreas
Cats
Salivary Glands
Atropine
Guinea Pigs

Keywords

  • Cyclic AMP
  • Muscarinic receptor stimulation
  • Pancreas
  • Submandibular gland
  • VIP

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland. / Enyedi, Péter; Fredholm, Bertil B.; Lundberg, Jan M.; Änggård, Anders.

In: European Journal of Pharmacology, Vol. 79, No. 1-2, 08.04.1982, p. 139-143.

Research output: Contribution to journalArticle

Enyedi, Péter ; Fredholm, Bertil B. ; Lundberg, Jan M. ; Änggård, Anders. / Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland. In: European Journal of Pharmacology. 1982 ; Vol. 79, No. 1-2. pp. 139-143.
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