Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana

Giuliano Delle Monache, Bruno Botta, Franco Delle Monache, Romulo Espinal, Stella C. De Bonnevaux, Carlo De Luca, Maurizio Botta, Federico Corelli, Donata Dei, E. Gács-Baitz, Marco Carmignani

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A second hypotensive agent from Verbesina caracasana is shown to be the truxinic type dimer of the previously isolated 3,4-dimethoxycinnamoyl guanidinoamide. The new compound gave by alkaline hydrolysis a crystalline monoamide, which in turn by acid hydrolysis gave 3',4'-dimethoxy-ß-truxinic acid, identical with a synthetic specimen.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number3
Publication statusPublished - 1996

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Verbesina
Hydrolysis
Acids
Dimers
Crystalline materials
caracasandiamide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Delle Monache, G., Botta, B., Delle Monache, F., Espinal, R., De Bonnevaux, S. C., De Luca, C., ... Carmignani, M. (1996). Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana. Bioorganic and Medicinal Chemistry Letters, 6(3), 233-238.

Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana. / Delle Monache, Giuliano; Botta, Bruno; Delle Monache, Franco; Espinal, Romulo; De Bonnevaux, Stella C.; De Luca, Carlo; Botta, Maurizio; Corelli, Federico; Dei, Donata; Gács-Baitz, E.; Carmignani, Marco.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 3, 1996, p. 233-238.

Research output: Contribution to journalArticle

Delle Monache, G, Botta, B, Delle Monache, F, Espinal, R, De Bonnevaux, SC, De Luca, C, Botta, M, Corelli, F, Dei, D, Gács-Baitz, E & Carmignani, M 1996, 'Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana', Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 3, pp. 233-238.
Delle Monache G, Botta B, Delle Monache F, Espinal R, De Bonnevaux SC, De Luca C et al. Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana. Bioorganic and Medicinal Chemistry Letters. 1996;6(3):233-238.
Delle Monache, Giuliano ; Botta, Bruno ; Delle Monache, Franco ; Espinal, Romulo ; De Bonnevaux, Stella C. ; De Luca, Carlo ; Botta, Maurizio ; Corelli, Federico ; Dei, Donata ; Gács-Baitz, E. ; Carmignani, Marco. / Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 3. pp. 233-238.
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