Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana

Giuliano Delle Monache, Bruno Botta, Franco Delle Monache, Romulo Espinal, Stella C. De Bonnevaux, Carlo De Luca, Maurizio Botta, Federico Corelli, Donata Dei, Eszter Gacs-Baitz, Marco Carmignani

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Abstract

A second hypotensive agent from Verbesina caracasana is shown to be the truxinic type dimer of the previously isolated 3,4-dimethoxycinnamoyl guanidinoamide. The new compound gave by alkaline hydrolysis a crystalline monoamide, which in turn by acid hydrolysis gave 3',4'-dimethoxy-ß-truxinic acid, identical with a synthetic specimen.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Delle Monache, G., Botta, B., Delle Monache, F., Espinal, R., De Bonnevaux, S. C., De Luca, C., Botta, M., Corelli, F., Dei, D., Gacs-Baitz, E., & Carmignani, M. (1996). Caracasandiamide, a truxinic hypotensive agent from verbesina caracasana. Bioorganic and Medicinal Chemistry Letters, 6(3), 233-238. https://doi.org/10.1016/0960-894X(96)00007-8