Capsaicin-sensitive sensory nerves and the trpv1 ion channel in cardiac physiology and pathologies

Tamara Szabados, Kamilla Gömöri, Laura Pálvölgyi, Anikó Görbe, István Baczkó, Zsuzsanna Helyes, Gábor Jancsó, Péter Ferdinandy, Péter Bencsik

Research output: Contribution to journalReview article


Cardiovascular diseases, including coronary artery disease, ischemic heart diseases such as acute myocardial infarction and postischemic heart failure, heart failure of other etiologies, and cardiac arrhythmias, belong to the leading causes of death. Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin-sensitive sensory nerves also contribute to the development and progression of some cardiac diseases, as well as to mechanisms of endogenous stress adaptation leading to cardioprotection. In this review, we summarize the role of capsaicin-sensitive afferents and the TRPV1 ion channel in physiological and pathophysiological functions of the heart based mainly on experimental results and show their diagnostic or therapeutic potentials. Although the actions of several other channels or receptors expressed on cardiac sensory afferents and the effects of TRPV1 channel activation on different non-neural cell types in the heart are not precisely known, most data suggest that stimulation of the TRPV1-expressing sensory nerves or stimulation/overexpression of TRPV1 channels have beneficial effects in cardiac diseases.

Original languageEnglish
Article number4472
Pages (from-to)1-23
Number of pages23
JournalInternational journal of molecular sciences
Issue number12
Publication statusPublished - Jun 23 2020


  • Acute myocardial infarction
  • Arrhythmia
  • Atherosclerosis
  • Capsaicin
  • Cardioprotection
  • Heart failure
  • Ischemic heart disease
  • Transient receptor potential vanilloid type 1 (TRPV1) receptor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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