Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle

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Abstract

Field stimulation of the isolated main bronchi of the guinea-pig results in a rapid contraction followed by a sustained contractile response. Tetrodotoxin abolished these effects. The first phase was strongly inhibited by hyoscine, indicating that it was mediated mainly by excitation of cholinergic nerves. The lasting contraction was abolished by capsaicin tachyphylaxis but it was resistant to the effects of hyoscine, hexamethonium or physostigmine. It is suggested that capsaicin-sensitive non-cholinergic nerves have major excitatory effect on the guinea-pig bronchial smooth muscle and there is also evidence for their influence on the trachea.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalNeuroscience Letters
Volume34
Issue number3
DOIs
Publication statusPublished - Dec 31 1982

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Keywords

  • airway innervation
  • capsaicin
  • guinea-pig
  • non-cholinergic bronchoconstriction
  • trachea

ASJC Scopus subject areas

  • Neuroscience(all)

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