Capsaicin-sensitive innervation of the guinea-pig taenia caeci

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. Stimulation (2-50 Hz) of the mesenteric nerves of the guinea-pig taenia caeci gave rise to contraction of the muscle obtained from animals pretreated with the adrenergic neuron-blocking agent guanethidine. Contraction was the response to stimulation at low frequencies (2-5 Hz) in about half of the untreated preparations as well. 2. The response was abolished by hyoscine (4.5×10-7 M), but was unaffected by the ganglionic blocking agent mecamylamine (4.9×10-5 M). Physostigmine (2.4×10-8 M) enhanced the contractions. 3. Capsaicin (9.8×10-6 M) elicited a contraction of the taenia caeci followed by a long-lasting tachyphylaxis. Contraction in response to stimulation of the mesenteric nerves was absent after this pretreatment. 4. Neither the response to direct excitation of the cholinergic neural elements of the myenteric plexus, nor the relaxation caused by stimulation of adrenergic fibres were influenced by capsaicin. "Purinergic" relaxation produced by field stimulation (0.5-10 Hz) remained also unchanged. 5. No functional evidence has been found for the presence of parasympathetic preganglionic fibres among the perivascular nerves supplying the taenia. 6. It is concluded that capsaicin-sensitive nerves excite cholinergic neurons of the myenteric plexus.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume309
Issue number1
DOIs
Publication statusPublished - Oct 1979

Fingerprint

Taenia
Capsaicin
Myenteric Plexus
Guinea Pigs
Ganglionic Blockers
Mecamylamine
Tachyphylaxis
Adrenergic Fibers
Guanethidine
Physostigmine
Cholinergic Neurons
Adrenergic Antagonists
Scopolamine Hydrobromide
Muscle Contraction
Adrenergic Agents
Cholinergic Agents

Keywords

  • Capsaicin
  • Cholinergic neurons
  • Large intestine innervation
  • Mecamylamine
  • Purinergic neurons

ASJC Scopus subject areas

  • Pharmacology

Cite this

Capsaicin-sensitive innervation of the guinea-pig taenia caeci. / Szolcsányi, J.; Barthó, L.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 309, No. 1, 10.1979, p. 77-82.

Research output: Contribution to journalArticle

@article{f6310cb6346f4e43b5eb399ef02a924b,
title = "Capsaicin-sensitive innervation of the guinea-pig taenia caeci",
abstract = "1. Stimulation (2-50 Hz) of the mesenteric nerves of the guinea-pig taenia caeci gave rise to contraction of the muscle obtained from animals pretreated with the adrenergic neuron-blocking agent guanethidine. Contraction was the response to stimulation at low frequencies (2-5 Hz) in about half of the untreated preparations as well. 2. The response was abolished by hyoscine (4.5×10-7 M), but was unaffected by the ganglionic blocking agent mecamylamine (4.9×10-5 M). Physostigmine (2.4×10-8 M) enhanced the contractions. 3. Capsaicin (9.8×10-6 M) elicited a contraction of the taenia caeci followed by a long-lasting tachyphylaxis. Contraction in response to stimulation of the mesenteric nerves was absent after this pretreatment. 4. Neither the response to direct excitation of the cholinergic neural elements of the myenteric plexus, nor the relaxation caused by stimulation of adrenergic fibres were influenced by capsaicin. {"}Purinergic{"} relaxation produced by field stimulation (0.5-10 Hz) remained also unchanged. 5. No functional evidence has been found for the presence of parasympathetic preganglionic fibres among the perivascular nerves supplying the taenia. 6. It is concluded that capsaicin-sensitive nerves excite cholinergic neurons of the myenteric plexus.",
keywords = "Capsaicin, Cholinergic neurons, Large intestine innervation, Mecamylamine, Purinergic neurons",
author = "J. Szolcs{\'a}nyi and L. Barth{\'o}",
year = "1979",
month = "10",
doi = "10.1007/BF00498759",
language = "English",
volume = "309",
pages = "77--82",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Capsaicin-sensitive innervation of the guinea-pig taenia caeci

AU - Szolcsányi, J.

AU - Barthó, L.

PY - 1979/10

Y1 - 1979/10

N2 - 1. Stimulation (2-50 Hz) of the mesenteric nerves of the guinea-pig taenia caeci gave rise to contraction of the muscle obtained from animals pretreated with the adrenergic neuron-blocking agent guanethidine. Contraction was the response to stimulation at low frequencies (2-5 Hz) in about half of the untreated preparations as well. 2. The response was abolished by hyoscine (4.5×10-7 M), but was unaffected by the ganglionic blocking agent mecamylamine (4.9×10-5 M). Physostigmine (2.4×10-8 M) enhanced the contractions. 3. Capsaicin (9.8×10-6 M) elicited a contraction of the taenia caeci followed by a long-lasting tachyphylaxis. Contraction in response to stimulation of the mesenteric nerves was absent after this pretreatment. 4. Neither the response to direct excitation of the cholinergic neural elements of the myenteric plexus, nor the relaxation caused by stimulation of adrenergic fibres were influenced by capsaicin. "Purinergic" relaxation produced by field stimulation (0.5-10 Hz) remained also unchanged. 5. No functional evidence has been found for the presence of parasympathetic preganglionic fibres among the perivascular nerves supplying the taenia. 6. It is concluded that capsaicin-sensitive nerves excite cholinergic neurons of the myenteric plexus.

AB - 1. Stimulation (2-50 Hz) of the mesenteric nerves of the guinea-pig taenia caeci gave rise to contraction of the muscle obtained from animals pretreated with the adrenergic neuron-blocking agent guanethidine. Contraction was the response to stimulation at low frequencies (2-5 Hz) in about half of the untreated preparations as well. 2. The response was abolished by hyoscine (4.5×10-7 M), but was unaffected by the ganglionic blocking agent mecamylamine (4.9×10-5 M). Physostigmine (2.4×10-8 M) enhanced the contractions. 3. Capsaicin (9.8×10-6 M) elicited a contraction of the taenia caeci followed by a long-lasting tachyphylaxis. Contraction in response to stimulation of the mesenteric nerves was absent after this pretreatment. 4. Neither the response to direct excitation of the cholinergic neural elements of the myenteric plexus, nor the relaxation caused by stimulation of adrenergic fibres were influenced by capsaicin. "Purinergic" relaxation produced by field stimulation (0.5-10 Hz) remained also unchanged. 5. No functional evidence has been found for the presence of parasympathetic preganglionic fibres among the perivascular nerves supplying the taenia. 6. It is concluded that capsaicin-sensitive nerves excite cholinergic neurons of the myenteric plexus.

KW - Capsaicin

KW - Cholinergic neurons

KW - Large intestine innervation

KW - Mecamylamine

KW - Purinergic neurons

UR - http://www.scopus.com/inward/record.url?scp=0018642693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018642693&partnerID=8YFLogxK

U2 - 10.1007/BF00498759

DO - 10.1007/BF00498759

M3 - Article

C2 - 522896

AN - SCOPUS:0018642693

VL - 309

SP - 77

EP - 82

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 1

ER -