Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula

Omar M E Abdel-Salam, Andras Debreceni, J. Szolcsányi, G. Mózsik

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of capsaicin on basal and pentagastrin-stimulated gastric acid secretion was investigated in the urethane anaesthetized acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15 min or by continuous gastric perfusion. Capsaicin given into the rat stomach at 120 ng · mL-1 prior to pentagastrin (25 μg · kg-1, iv) reduced gastric acid secretory response to pentagastrin by 24%. Intravenous (iv) capsaicin (0.5 μg · kg-1) did not reduce the pentagastrin-stimulated gastric acid secretion. After topical capsaicin desensitization (3 mg · mL-1), basal gastric acid secretion and that in response to pentagastrin (25 μg · kg-1, intraperitonaeally) was unaltered compared with the control group. Data indicate that topical capsaicin inhibits gastric acid secretion stimulated with pentagastrin in anaesthetized rats.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalJournal of Physiology Paris
Volume93
Issue number5
DOIs
Publication statusPublished - Nov 1999

Fingerprint

Gastric Fistula
Pentagastrin
Capsaicin
Gastric Acid
Stomach
Urethane
Perfusion
Control Groups

Keywords

  • Capsaicin
  • Gastric acid secretion
  • Pentagastrin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula. / Abdel-Salam, Omar M E; Debreceni, Andras; Szolcsányi, J.; Mózsik, G.

In: Journal of Physiology Paris, Vol. 93, No. 5, 11.1999, p. 461-466.

Research output: Contribution to journalArticle

@article{2d9f6bfc45cb4e9a8f3e86f2f7c76785,
title = "Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula",
abstract = "The effect of capsaicin on basal and pentagastrin-stimulated gastric acid secretion was investigated in the urethane anaesthetized acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15 min or by continuous gastric perfusion. Capsaicin given into the rat stomach at 120 ng · mL-1 prior to pentagastrin (25 μg · kg-1, iv) reduced gastric acid secretory response to pentagastrin by 24{\%}. Intravenous (iv) capsaicin (0.5 μg · kg-1) did not reduce the pentagastrin-stimulated gastric acid secretion. After topical capsaicin desensitization (3 mg · mL-1), basal gastric acid secretion and that in response to pentagastrin (25 μg · kg-1, intraperitonaeally) was unaltered compared with the control group. Data indicate that topical capsaicin inhibits gastric acid secretion stimulated with pentagastrin in anaesthetized rats.",
keywords = "Capsaicin, Gastric acid secretion, Pentagastrin",
author = "Abdel-Salam, {Omar M E} and Andras Debreceni and J. Szolcs{\'a}nyi and G. M{\'o}zsik",
year = "1999",
month = "11",
doi = "10.1016/S0928-4257(99)00113-8",
language = "English",
volume = "93",
pages = "461--466",
journal = "Journal de Physiologie",
issn = "0928-4257",
publisher = "Elsevier Masson SAS",
number = "5",

}

TY - JOUR

T1 - Capsaicin inhibits the pentagastrin-stimulated gastric acid secretion in anaesthetized rats with acute gastric fistula

AU - Abdel-Salam, Omar M E

AU - Debreceni, Andras

AU - Szolcsányi, J.

AU - Mózsik, G.

PY - 1999/11

Y1 - 1999/11

N2 - The effect of capsaicin on basal and pentagastrin-stimulated gastric acid secretion was investigated in the urethane anaesthetized acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15 min or by continuous gastric perfusion. Capsaicin given into the rat stomach at 120 ng · mL-1 prior to pentagastrin (25 μg · kg-1, iv) reduced gastric acid secretory response to pentagastrin by 24%. Intravenous (iv) capsaicin (0.5 μg · kg-1) did not reduce the pentagastrin-stimulated gastric acid secretion. After topical capsaicin desensitization (3 mg · mL-1), basal gastric acid secretion and that in response to pentagastrin (25 μg · kg-1, intraperitonaeally) was unaltered compared with the control group. Data indicate that topical capsaicin inhibits gastric acid secretion stimulated with pentagastrin in anaesthetized rats.

AB - The effect of capsaicin on basal and pentagastrin-stimulated gastric acid secretion was investigated in the urethane anaesthetized acute gastric fistula rat. Gastric acid secretion was measured by flushing of the gastric lumen with saline every 15 min or by continuous gastric perfusion. Capsaicin given into the rat stomach at 120 ng · mL-1 prior to pentagastrin (25 μg · kg-1, iv) reduced gastric acid secretory response to pentagastrin by 24%. Intravenous (iv) capsaicin (0.5 μg · kg-1) did not reduce the pentagastrin-stimulated gastric acid secretion. After topical capsaicin desensitization (3 mg · mL-1), basal gastric acid secretion and that in response to pentagastrin (25 μg · kg-1, intraperitonaeally) was unaltered compared with the control group. Data indicate that topical capsaicin inhibits gastric acid secretion stimulated with pentagastrin in anaesthetized rats.

KW - Capsaicin

KW - Gastric acid secretion

KW - Pentagastrin

UR - http://www.scopus.com/inward/record.url?scp=0033385707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033385707&partnerID=8YFLogxK

U2 - 10.1016/S0928-4257(99)00113-8

DO - 10.1016/S0928-4257(99)00113-8

M3 - Article

VL - 93

SP - 461

EP - 466

JO - Journal de Physiologie

JF - Journal de Physiologie

SN - 0928-4257

IS - 5

ER -