Capsaicin-induced nonneural vasoconstriction in canine mesenteric arteries

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Abstract

Prolonged cold storage (4°C) of canine mesenteric arteries was used to reveal the role of nonneural mechanisms in capsaicin-induced vascular contraction. The EC50 values of capsaicin were 3.0 μM, 670 and 104 nM in preparations made fresh, after a 1- or 2-week period of cold storage, respectively, indicating an enhanced contractile responsiveness of the denervated tissue to capsaicin. A similar exaggerated contractile response was seen with phenylephrine exclusively after a 1-week cold storage. For fresh, 1- and 2-week cold-stored arteries, the EC50 of phenylephrine were 248, 38 and 30 nM, respectively. The maximum contraction produced by tyramine was decreased with time. The results suggest that capsaicin may attain vasoconstriction independent of neural elements.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalEuropean Journal of Pharmacology
Volume441
Issue number3
DOIs
Publication statusPublished - Apr 26 2002

Keywords

  • Capsaicin
  • Cold storage
  • Vasoconstriction

ASJC Scopus subject areas

  • Pharmacology

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