Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor

D. C M Taylor, Fr K. Pierau, J. Szolcsányi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Capsaicin injected into the scrotal skin of rats was observed to induce a decrease in the amount of horseradish peroxidase (HRP) transported in the pudendal nerve to the sixth lumbar dorsal root ganglion on the pretreated side. This was seen as a decrease in the number of HRP-labelled neurones compared to the control side. A morphometric study confirmed that the effect of capsaicin was exerted predominantly on the small neurones. Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.

Original languageEnglish
Pages (from-to)569-573
Number of pages5
JournalCell and Tissue Research
Volume240
Issue number3
DOIs
Publication statusPublished - Jun 1985

Fingerprint

Axonal Transport
Capsaicin
Nerve Growth Factor
Pudendal Nerve
Horseradish Peroxidase
Neurons
Spinal Ganglia
Peripheral Nerves
Rats
Skin
Injections

Keywords

  • Axoplasmic transport
  • Capsaicin
  • Dorsal root ganglion
  • Horseradish peroxydase (HRP)
  • Nerve growth factor (NGF)
  • Neurones

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor. / Taylor, D. C M; Pierau, Fr K.; Szolcsányi, J.

In: Cell and Tissue Research, Vol. 240, No. 3, 06.1985, p. 569-573.

Research output: Contribution to journalArticle

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