Capillary electrophoresis separation of enantiomers using cyclodextrin array chiral analysis

András Guttman, Sandra Brunet, Nelson Cooke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Method development of chiral analyses has been characterized as one of the most challenging separation problems. Because of the wide diversity of chemical structures in pharmaceutical drug substances and the plethora of chiral selectors, these analyses have historically resulted in time-consuming searches for optimum separation conditions. In conventional techniques such as gas and high performance liquid chromatography, the lack of a generalized chiral optimization scheme (other than the traditional hit-or-miss approach) has exacerbated the problem. In this article, the authors describe a fast capillary electrophoresis procedure for the enantiomeric separation of acidic and basic pharmaceuticals using native and modified cyclodextrins. They call their technique cyclodextrin array chiral analysis.

Original languageEnglish
Pages (from-to)88-100
Number of pages13
JournalLC GC Europe
Volume9
Issue number2
Publication statusPublished - Feb 1996

ASJC Scopus subject areas

  • Analytical Chemistry

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