Cannabinoid signaling in the skin: Therapeutic potential of the "c(ut)annabinoid" system

Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, Attila Oláh

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid ("c[ut]annabinoid") signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regeneration, and its dysregulation was implicated to contribute to several highly prevalent diseases and disorders, e.g., atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. The current review aims to give an overview of the available skin-relevant endo- and phytocannabinoid literature with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges.

Original languageEnglish
Article number24050918
JournalMolecules
Volume24
Issue number5
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • acne
  • atopic dermatitis
  • cannabinoid
  • fibrosis
  • hair growth
  • inflammation
  • itch
  • psoriasis
  • skin
  • tumor
  • wound healing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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