Candidate susceptibility genes in Alzheimer's disease are at high risk for being forgotten - They don't give peace of mind...

András Palotás, János Kálmán

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.

Original languageEnglish
Pages (from-to)273-293
Number of pages21
JournalCurrent Drug Metabolism
Volume7
Issue number3
DOIs
Publication statusPublished - Apr 1 2006

Keywords

  • Allele
  • Alzheimer's disease
  • Determinative gene
  • Linkage analysis
  • Polymorphism
  • Risk factor
  • Risk gene
  • Susceptibility gene

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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