Dopaminerg és szerotonerg polimorfizmusok kandidáns génvizsgálatai

Translated title of the contribution: Candidate gene studies of dopaminergic and serotonergic polymorphisms

Gabor Varga, A. Székely, M. Sasvári

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The most researched candidate genes of psychiatric genetic association studies are the components of the monoamine neurotransmitter systems, out of which serotonin and dopamine transmitter systems gained particular attention due to their major role in regulating emotional functions and cognitive processes. The paper reviews association studies focusing on the polymorphisms of receptors, transporters and enzymes that belong to these two transmitter systems. Numerous studies demonstrated significant associations between serotonergic and dopaminergic polymorphisms and diagnostic categories, personality traits and cognitive functions, however, results of monoamine gene variants and psychological properties are often contradictory. The contradictions can partially be explained with relatively small sample sizes of earlier studies, heterogeneity of methods across the studies and our expanding knowledge of the function of polymorphisms. On the whole, however, it can be declared that psychogenetic research plays an important role in the development of personalized pharmacotherapy.

Original languageHungarian
Pages (from-to)93-101
Number of pages9
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number2
Publication statusPublished - Jun 2011

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Cognition
Behavioral Genetics
Genetic Association Studies
Sample Size
Genes
Neurotransmitter Agents
Psychiatry
Personality
Dopamine
Serotonin
Psychology
Drug Therapy
Enzymes
Research

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Dopaminerg és szerotonerg polimorfizmusok kandidáns génvizsgálatai. / Varga, Gabor; Székely, A.; Sasvári, M.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 2, 06.2011, p. 93-101.

Research output: Contribution to journalArticle

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