Candida antarctica lipase A - A powerful catalyst for the resolution of heteroaromatic β-amino esters

Magdolna Solymár, Ferenc Fülöp, Liisa T. Kanerva

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Enantioselective acylations of 3-amino-3-heteroarylpropanoates (ArCH(NH2)CH2CO2Et; Ar=2- or 3-thienyl or -furyl) were performed in the presence of Candida antarctica lipase A. As a result of the excellent chemo- and enantioselectivities (E >100), gram-scale resolutions were carried out in ethyl butanoate. The hydrochloride salts of the unreacted R substrates and the butanamides of the reactive S enantiomers were thus prepared.

Original languageEnglish
Pages (from-to)2383-2388
Number of pages6
JournalTetrahedron Asymmetry
Volume13
Issue number21
DOIs
Publication statusPublished - Oct 31 2002

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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