Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: A study of kiwifruit extracts

Noboru Motohashi, Yoshiaki Shirataki, Masami Kawase, Satoru Tani, Hiroshi Sakagami, Kazue Satoh, Teruo Kurihara, Hideki Nakashima, I. Mucsi, Andreas Varga, J. Molnár

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70% methanol, and further fractionated by silica gel and ODS column chromatographies for the assays of various biological activities. Five fractions H1, H2 (hexane extract), A1, A2 (acetone extract) and M2 (methanol extract) showed selective cytotoxic activity against human oral tumor cell lines, which was more sensitive than human gingival fibroblasts. More hydrophilic fractions [70M3, 70M4, 70M5] of 70% methanol extract displayed higher anti-HIV activity, radical generation and O2 - scavenging activity. The antibacterial activity of 70% methanol extracts [70M0, 70M1, 70M2, 70M3, 70M4] was generally lower than that of more lipophilic fractions (hexane, acetone, methanol extracts), although each fraction did not show any specific antimicrobial action. All fractions were inactive against Helicobacter pylori. These results demonstrate that gold kiwifruit extracts contain valuable, various bioactive materials, which can be separated with each other.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalJournal of Ethnopharmacology
Volume81
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Folklore
Methanol
Medicine
Hexanes
Acetone
Neoplasms
Gold
Therapeutics
Silica Gel
Tumor Cell Line
varespladib methyl
Human Activities
Helicobacter pylori
Biological Assay
Chromatography
Fruit
Fibroblasts
HIV

Keywords

  • Actinidiaceae
  • Antimicrobial activity
  • Cytotoxic activity
  • Kiwifruit fractions
  • Radical intensity

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cancer prevention and therapy with kiwifruit in Chinese folklore medicine : A study of kiwifruit extracts. / Motohashi, Noboru; Shirataki, Yoshiaki; Kawase, Masami; Tani, Satoru; Sakagami, Hiroshi; Satoh, Kazue; Kurihara, Teruo; Nakashima, Hideki; Mucsi, I.; Varga, Andreas; Molnár, J.

In: Journal of Ethnopharmacology, Vol. 81, No. 3, 2002, p. 357-364.

Research output: Contribution to journalArticle

Motohashi, N, Shirataki, Y, Kawase, M, Tani, S, Sakagami, H, Satoh, K, Kurihara, T, Nakashima, H, Mucsi, I, Varga, A & Molnár, J 2002, 'Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: A study of kiwifruit extracts', Journal of Ethnopharmacology, vol. 81, no. 3, pp. 357-364. https://doi.org/10.1016/S0378-8741(02)00125-3
Motohashi, Noboru ; Shirataki, Yoshiaki ; Kawase, Masami ; Tani, Satoru ; Sakagami, Hiroshi ; Satoh, Kazue ; Kurihara, Teruo ; Nakashima, Hideki ; Mucsi, I. ; Varga, Andreas ; Molnár, J. / Cancer prevention and therapy with kiwifruit in Chinese folklore medicine : A study of kiwifruit extracts. In: Journal of Ethnopharmacology. 2002 ; Vol. 81, No. 3. pp. 357-364.
@article{c0478eccfc8542a1b3d56e1607aadf07,
title = "Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: A study of kiwifruit extracts",
abstract = "Kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70{\%} methanol, and further fractionated by silica gel and ODS column chromatographies for the assays of various biological activities. Five fractions H1, H2 (hexane extract), A1, A2 (acetone extract) and M2 (methanol extract) showed selective cytotoxic activity against human oral tumor cell lines, which was more sensitive than human gingival fibroblasts. More hydrophilic fractions [70M3, 70M4, 70M5] of 70{\%} methanol extract displayed higher anti-HIV activity, radical generation and O2 - scavenging activity. The antibacterial activity of 70{\%} methanol extracts [70M0, 70M1, 70M2, 70M3, 70M4] was generally lower than that of more lipophilic fractions (hexane, acetone, methanol extracts), although each fraction did not show any specific antimicrobial action. All fractions were inactive against Helicobacter pylori. These results demonstrate that gold kiwifruit extracts contain valuable, various bioactive materials, which can be separated with each other.",
keywords = "Actinidiaceae, Antimicrobial activity, Cytotoxic activity, Kiwifruit fractions, Radical intensity",
author = "Noboru Motohashi and Yoshiaki Shirataki and Masami Kawase and Satoru Tani and Hiroshi Sakagami and Kazue Satoh and Teruo Kurihara and Hideki Nakashima and I. Mucsi and Andreas Varga and J. Moln{\'a}r",
year = "2002",
doi = "10.1016/S0378-8741(02)00125-3",
language = "English",
volume = "81",
pages = "357--364",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Cancer prevention and therapy with kiwifruit in Chinese folklore medicine

T2 - A study of kiwifruit extracts

AU - Motohashi, Noboru

AU - Shirataki, Yoshiaki

AU - Kawase, Masami

AU - Tani, Satoru

AU - Sakagami, Hiroshi

AU - Satoh, Kazue

AU - Kurihara, Teruo

AU - Nakashima, Hideki

AU - Mucsi, I.

AU - Varga, Andreas

AU - Molnár, J.

PY - 2002

Y1 - 2002

N2 - Kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70% methanol, and further fractionated by silica gel and ODS column chromatographies for the assays of various biological activities. Five fractions H1, H2 (hexane extract), A1, A2 (acetone extract) and M2 (methanol extract) showed selective cytotoxic activity against human oral tumor cell lines, which was more sensitive than human gingival fibroblasts. More hydrophilic fractions [70M3, 70M4, 70M5] of 70% methanol extract displayed higher anti-HIV activity, radical generation and O2 - scavenging activity. The antibacterial activity of 70% methanol extracts [70M0, 70M1, 70M2, 70M3, 70M4] was generally lower than that of more lipophilic fractions (hexane, acetone, methanol extracts), although each fraction did not show any specific antimicrobial action. All fractions were inactive against Helicobacter pylori. These results demonstrate that gold kiwifruit extracts contain valuable, various bioactive materials, which can be separated with each other.

AB - Kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70% methanol, and further fractionated by silica gel and ODS column chromatographies for the assays of various biological activities. Five fractions H1, H2 (hexane extract), A1, A2 (acetone extract) and M2 (methanol extract) showed selective cytotoxic activity against human oral tumor cell lines, which was more sensitive than human gingival fibroblasts. More hydrophilic fractions [70M3, 70M4, 70M5] of 70% methanol extract displayed higher anti-HIV activity, radical generation and O2 - scavenging activity. The antibacterial activity of 70% methanol extracts [70M0, 70M1, 70M2, 70M3, 70M4] was generally lower than that of more lipophilic fractions (hexane, acetone, methanol extracts), although each fraction did not show any specific antimicrobial action. All fractions were inactive against Helicobacter pylori. These results demonstrate that gold kiwifruit extracts contain valuable, various bioactive materials, which can be separated with each other.

KW - Actinidiaceae

KW - Antimicrobial activity

KW - Cytotoxic activity

KW - Kiwifruit fractions

KW - Radical intensity

UR - http://www.scopus.com/inward/record.url?scp=0035996890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035996890&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(02)00125-3

DO - 10.1016/S0378-8741(02)00125-3

M3 - Article

C2 - 12127237

AN - SCOPUS:0035996890

VL - 81

SP - 357

EP - 364

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 3

ER -