Daganatok kemoprevenciója

Translated title of the contribution: Cancer chemoprevention

Research output: Contribution to journalArticle

Abstract

Elimination of tumour mass with one of the modalities in oncotherapy (surgery, radiotherapy, chemotherapy) has been shown a significant progress in the management of cancer patients. At present however considerate interests are focused also on chemoprevention which aims to block the formation and also the progression of tumours. Investigations on tumour formation indicate that both blocking the transition of premalignant lesions, - such as dysplasia, intraepithelial neoplasis, - to malignant tumours and the recurrences of the malignant diseases after surgery could be prevented by chemical agents. At present the following class of drugs have listed among the agents showing cancer chemopreventive potency in the clinical studies: Derivatives of Vitamin A and D, antioestrogens, antiandrogens, and the family of the non-steroid- antiinflammatory agents. Noteworthy that several highly promising chemical compounds have been purified from plants which are associated with anticancer potency and their activity against certain molecular or cellular events closely related to malignant phenotype have been concluded in preclinical studies. These compounds are now available for prospective double blind clinical trials to obtain evidence based data on their values and proper application in the human populations.

Original languageHungarian
Pages (from-to)129-135
Number of pages7
JournalOrvoskepzes
Volume78
Issue number4
Publication statusPublished - 2003

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Chemoprevention
Neoplasms
Androgen Antagonists
Estrogen Receptor Modulators
Vitamin A
Vitamin D
Anti-Inflammatory Agents
Radiotherapy
Clinical Trials
Phenotype
Recurrence
Drug Therapy
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Daganatok kemoprevenciója. / Jeney, A.

In: Orvoskepzes, Vol. 78, No. 4, 2003, p. 129-135.

Research output: Contribution to journalArticle

Jeney, A 2003, 'Daganatok kemoprevenciója', Orvoskepzes, vol. 78, no. 4, pp. 129-135.
Jeney, A. / Daganatok kemoprevenciója. In: Orvoskepzes. 2003 ; Vol. 78, No. 4. pp. 129-135.
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