Abstract
This paper disputes the suggestion of Hipkiss [Hipkiss, A., 2006. On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem? Mech. Ageing Dev. 127, 8-15], according to which dietary restriction by decreasing methylglyoxal production may prevent ageing. A list of arguments is given to support the refusal of hypothesis: (i) it has never been proven that the main source of methylglyoxal is its formation from triose-phosphate intermediates of glycolysis; (ii) the above note particularly applies to pathological conditions as acetone breakdown and amino acid metabolism also come into picture under these circumstances; (iii) glycolysis is of vital importance, thus its inhibition or a sharp restriction of carbohydrate uptake are unlikely beneficial for those tissues that are exclusively dependent on glycolysis in the regard of their energy production. Taken these concerns into account and considered all the promising attempts to influence the toxic effects of methylglyoxal, it is feared that the theory, as it is, cannot offer benefit to prevent ageing.
| Original language | English |
|---|---|
| Pages (from-to) | 227-228 |
| Number of pages | 2 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 128 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2007 |
Fingerprint
Keywords
- Acetone
- Aminoacetone
- Dietary restriction
- Glycolysis
- Methylglyoxal
ASJC Scopus subject areas
- Ageing
- Biochemistry
- Developmental Biology
- Developmental Neuroscience
Cite this
Can ageing be prevented by dietary restriction? / Kalapos, M.
In: Mechanisms of Ageing and Development, Vol. 128, No. 2, 02.2007, p. 227-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Can ageing be prevented by dietary restriction?
AU - Kalapos, M.
PY - 2007/2
Y1 - 2007/2
N2 - This paper disputes the suggestion of Hipkiss [Hipkiss, A., 2006. On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem? Mech. Ageing Dev. 127, 8-15], according to which dietary restriction by decreasing methylglyoxal production may prevent ageing. A list of arguments is given to support the refusal of hypothesis: (i) it has never been proven that the main source of methylglyoxal is its formation from triose-phosphate intermediates of glycolysis; (ii) the above note particularly applies to pathological conditions as acetone breakdown and amino acid metabolism also come into picture under these circumstances; (iii) glycolysis is of vital importance, thus its inhibition or a sharp restriction of carbohydrate uptake are unlikely beneficial for those tissues that are exclusively dependent on glycolysis in the regard of their energy production. Taken these concerns into account and considered all the promising attempts to influence the toxic effects of methylglyoxal, it is feared that the theory, as it is, cannot offer benefit to prevent ageing.
AB - This paper disputes the suggestion of Hipkiss [Hipkiss, A., 2006. On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem? Mech. Ageing Dev. 127, 8-15], according to which dietary restriction by decreasing methylglyoxal production may prevent ageing. A list of arguments is given to support the refusal of hypothesis: (i) it has never been proven that the main source of methylglyoxal is its formation from triose-phosphate intermediates of glycolysis; (ii) the above note particularly applies to pathological conditions as acetone breakdown and amino acid metabolism also come into picture under these circumstances; (iii) glycolysis is of vital importance, thus its inhibition or a sharp restriction of carbohydrate uptake are unlikely beneficial for those tissues that are exclusively dependent on glycolysis in the regard of their energy production. Taken these concerns into account and considered all the promising attempts to influence the toxic effects of methylglyoxal, it is feared that the theory, as it is, cannot offer benefit to prevent ageing.
KW - Acetone
KW - Aminoacetone
KW - Dietary restriction
KW - Glycolysis
KW - Methylglyoxal
UR - http://www.scopus.com/inward/record.url?scp=33846247901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846247901&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2006.11.027
DO - 10.1016/j.mad.2006.11.027
M3 - Article
C2 - 17145073
AN - SCOPUS:33846247901
VL - 128
SP - 227
EP - 228
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 2
ER -