Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells

Marianna Pintér, András Aszódi, Peter Friedrich, Irith Ginzburg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalNeuroscience Letters
Volume170
Issue number1
DOIs
Publication statusPublished - Mar 28 1994

Keywords

  • Calpain
  • Calpeptin
  • Differentiation
  • NGF
  • Neurite growth
  • PC12

ASJC Scopus subject areas

  • Neuroscience(all)

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