Calorimetric study of the effects of 2,4-dichlorophenol on the thermotropic phase behavior of DPPC liposomes

Á Csiszár, A. Bóta, Cs Novák, E. Klumpp, G. Subklew

Research output: Contribution to journalArticle

14 Citations (Scopus)


The effect of 2,4-dichlorophenol (DCP) on the main transition and pretransition of fully hydrated (20 mass%) dipalmitoylphosphatidylcholine (DPPC) multilamellar liposomes has been studied by differential scanning calorimetry (DSC). It was observed that an increase in the molar ratio of DCP/DPPC (from 4·10-5 up to 2·10-2) causes progressive reductions in the temperature and enthalpy of the pretransition. The higher concentration of DCP eliminates the pretransition. The influence of DCP on the main transition in this molar ratio range is not drastic, but a decrease in temperature and in the enthalpy values was observed. In the molar ratio range (from 2·10-1 up to 4·10-1) the DSC scans show multiple main transition peaks instead of the characteristic single peak of the main transition. Above a DCP/DPPC molar ratio of 0.6 a new peak appears at 25°C having about the same transition enthalpy as the main transition of the pure system.

Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalJournal of Thermal Analysis and Calorimetry
Issue number1
Publication statusPublished - Aug 26 2002



  • 2,4-dichlorophenol
  • DPPC liposomes
  • DSC
  • Freeze-fracture
  • Model membranes
  • Phase transition

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this