Calorimetric investigation of rat myometrium as a function of gestational age

István Zupkó, Gábor Csík, George Falkay, Géza Regdon Jr, Dénes Lorinczy

Research output: Contribution to journalArticle

Abstract

The aim of the present work was the characterization of the myometrial samples of healthy control and chronic inflammation-exposed rats as a function of gestational stage by means of differential scanning calorimetry (DSC). Non-pregnant, mid-pregnant (day 14) and late-pregnant (day 21) animals were included. The spontaneous, KCl-stimulated as well as maximal motor activity was additionally recorded in vitro. Calorimetric enthalpy (ΔH) normalised on wet mass significantly increased as pregnancy progressed in case of non-inflamed uteri. Inflammation resulted in a significant decrease in ΔH/m of samples from non-pregnant till pregnant rats. Maximal contractility increased by inflammation in all tested stages of gestation. Our present results indicate that DSC can be considered as a useful tool for the investigation of the uterine function modified by gestation or a pathological condition.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalThermochimica Acta
Volume496
Issue number1-2
DOIs
Publication statusPublished - Dec 10 2009

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Keywords

  • DSC
  • Inflammation
  • Pregnancy
  • Rat
  • Uterus

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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