Calculation of cyclodextrin-mediated enantiomer ratio shifting of racem norgestrel in aqueous solutions

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Abstract

Enantioselective solubility of rac-norgestrel was found in the presence of γ-cyclodextrin or hydroxypropyl-γ-cyclodextrin. In both cases the efficacious enantiomer was dissolved in greater extent. Calculating the molar absorptivity and molar ellipticity spectra of the γ- and hydroxypropyl-γ-cyclodextrin aqueous complexes, a simple and rapid direct circular dichroism (CD) spectrometric method was obtained for the determination of the enantiomer ratio in aqueous solutions.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume57
Issue number1-4
DOIs
Publication statusPublished - Apr 1 2007

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Keywords

  • Circular dichroism
  • Enantioselective solubility
  • HP-γ-cyclodextrin
  • Inclusion complexes
  • Molar absorptivity
  • Molar ellipticity
  • Norgestrel
  • γ-cyclodextrin

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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