Az amyotrophiás lateralsclerosis patofiziológiai tényezoinek központi kapcsolóeleme, a kalcium

Translated title of the contribution: Calciumion is a common denominator in the pathophysiological processes of amyotrophic lateral sclerosis

Roland Patai, Bernát Nógrádi, Valéria Meszlényi, Izabella Obál, J. Engelhardt, L. Siklós

Research output: Contribution to journalReview article

Abstract

Amyotrophic lateral sclerosis (ALS), the most frequent motor neuron disease is characterized by progressive muscle weakness caused by the degeneration of the motor neurons in the spinal cord and motor cortex. However, according to the recent observations, ALS is a rather complex syndrome which frequently involves symptoms of cognitive impairment. Therefore, ALS cases can be interpreted in a clinico-pathological spectrum spanning from the classical ALS involving only the motor system to the fronto-temporal dementia. The progression of the disease, however, manifested in the degeneration of the upper and lower motor neurons, is based on the same complex pathobiology. The main elements of the pathomechanism, such as oxidative stress, excitotoxicity, immune/inflammatory processes and mitochondrial dysfunction are well described already, which operate in orchestrated way and amplify the deleterious effect of each other. It is assumed that calcium ions act as a catalyst in this interaction, hence each of the individual mechanisms has strong, positive and reciprocal calcium dependence thus may combine the individual pathological processes into a unified escalating mechanism of neuronal destruction. This review provides an overview of the role of calcium in connecting and amplifying the major mechanisms which lead to degeneration of the motor neurons in ALS.

Translated title of the contributionCalciumion is a common denominator in the pathophysiological processes of amyotrophic lateral sclerosis
Original languageHungarian
Pages (from-to)247-257
Number of pages11
JournalIdeggyogyaszati Szemle
Volume70
Issue number7-8
DOIs
Publication statusPublished - Jul 30 2017

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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