Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells

M. Deli, Ferenc Joó, I. Krizbai, Imre Lengyel, Maria G. Nunzi, Joachim R. Wolff

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Calcium/calmodulin-stimulated protein kinase II (CaM-PK II), a major kinase in brain, has been established to play an important role in neurotransmitter release and organization of postsynaptic receptors, and it is known to be involved in long-term potentiation and memory. Less is known about the function of this enzyme in nonneural cells. Here we report on the production, presence, and phosphorylation of the α-subunit of CaM-PK II in primary cultures of cerebral endothelial cells. These results raise the possibility that α-CaM-PK II can act as one of the key enzymes of calcium-mediated intracellular signaling in the cerebral endothelial cells and suggest that α-CaM-PK II may participate in such basic cellular processes as permeability in physiological and pathological conditions.

Original languageEnglish
Pages (from-to)1960-1963
Number of pages4
JournalJournal of Neurochemistry
Volume60
Issue number5
Publication statusPublished - May 1993

Fingerprint

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Endothelial cells
Calmodulin
Cell culture
Protein Kinases
Endothelial Cells
Calcium
Long-Term Memory
Long-Term Potentiation
Enzymes
Phosphorylation
Neurotransmitter Agents
Permeability
Phosphotransferases
Brain
Data storage equipment

Keywords

  • Blood-brain barrier
  • Calcium/calmodulin-stimulated protein kinase II
  • Cerebral endothelial cells
  • Protein phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells. / Deli, M.; Joó, Ferenc; Krizbai, I.; Lengyel, Imre; Nunzi, Maria G.; Wolff, Joachim R.

In: Journal of Neurochemistry, Vol. 60, No. 5, 05.1993, p. 1960-1963.

Research output: Contribution to journalArticle

Deli, M. ; Joó, Ferenc ; Krizbai, I. ; Lengyel, Imre ; Nunzi, Maria G. ; Wolff, Joachim R. / Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells. In: Journal of Neurochemistry. 1993 ; Vol. 60, No. 5. pp. 1960-1963.
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